Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1119494..1119992 Replicon chromosome
Accession NZ_LR129844
Organism Streptococcus pneumoniae strain 180-15 isolate 180-15

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EQB47_RS06015 Protein ID WP_001812387.1
Coordinates 1119494..1119748 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQB47_RS06020 Protein ID WP_000208080.1
Coordinates 1119750..1119992 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB47_RS06000 1114755..1117223 - 2469 WP_001152997.1 DNA gyrase subunit A -
EQB47_RS06005 1117417..1118403 + 987 WP_000204733.1 L-lactate dehydrogenase -
EQB47_RS06010 1118752..1119447 - 696 WP_000731127.1 potassium channel family protein -
EQB47_RS06015 1119494..1119748 - 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQB47_RS06020 1119750..1119992 - 243 WP_000208080.1 hypothetical protein Antitoxin
EQB47_RS06025 1120083..1120892 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQB47_RS06030 1120894..1122243 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQB47_RS06035 1122236..1122940 - 705 WP_000722076.1 response regulator transcription factor -
EQB47_RS06040 1122995..1124170 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.85 Da        Isoelectric Point: 10.7632

>T286115 WP_001812387.1 NZ_LR129844:c1119748-1119494 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT286115 WP_000208080.1 NZ_LR129844:c1119992-1119750 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References