Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1119525..1120023 Replicon chromosome
Accession NZ_LR129843
Organism Streptococcus pneumoniae strain 180-2 isolate 180-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EQB46_RS06015 Protein ID WP_001812387.1
Coordinates 1119525..1119779 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQB46_RS06020 Protein ID WP_000208080.1
Coordinates 1119781..1120023 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB46_RS06000 1114786..1117254 - 2469 WP_001152997.1 DNA gyrase subunit A -
EQB46_RS06005 1117448..1118434 + 987 WP_000204733.1 L-lactate dehydrogenase -
EQB46_RS06010 1118783..1119478 - 696 WP_000731127.1 potassium channel family protein -
EQB46_RS06015 1119525..1119779 - 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQB46_RS06020 1119781..1120023 - 243 WP_000208080.1 hypothetical protein Antitoxin
EQB46_RS06025 1120114..1120923 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQB46_RS06030 1120925..1122274 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQB46_RS06035 1122267..1122971 - 705 WP_000722076.1 response regulator transcription factor -
EQB46_RS06040 1123026..1124201 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.85 Da        Isoelectric Point: 10.7632

>T286112 WP_001812387.1 NZ_LR129843:c1119779-1119525 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT286112 WP_000208080.1 NZ_LR129843:c1120023-1119781 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References