Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 3420737..3421162 Replicon chromosome
Accession NC_019779
Organism Halothece sp. PCC 7418 (Aphanothece halophytica 7418)

Toxin (Protein)


Gene name hicA Uniprot ID K9YFN2
Locus tag PCC7418_RS15690 Protein ID WP_015227169.1
Coordinates 3420974..3421162 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID K9YEB2
Locus tag PCC7418_RS15685 Protein ID WP_015227168.1
Coordinates 3420737..3420952 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCC7418_RS15660 3416483..3417631 + 1149 WP_015227162.1 iron-containing alcohol dehydrogenase family protein -
PCC7418_RS15665 3417652..3418833 + 1182 WP_015227163.1 aspartate aminotransferase -
PCC7418_RS15670 3418966..3419697 + 732 WP_015227164.1 class I SAM-dependent methyltransferase -
PCC7418_RS15675 3420053..3420316 - 264 WP_015227166.1 type II toxin-antitoxin system RelE/ParE family toxin -
PCC7418_RS15680 3420313..3420537 - 225 WP_015227167.1 hypothetical protein -
PCC7418_RS15685 3420737..3420952 - 216 WP_015227168.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PCC7418_RS15690 3420974..3421162 - 189 WP_015227169.1 type II toxin-antitoxin system HicA family toxin Toxin
PCC7418_RS15695 3421293..3421568 - 276 WP_015227170.1 hypothetical protein -
PCC7418_RS15700 3422035..3422688 - 654 WP_015227171.1 GIY-YIG nuclease family protein -
PCC7418_RS15705 3422786..3423070 - 285 WP_015227172.1 hypothetical protein -
PCC7418_RS15710 3423060..3423356 - 297 WP_015227173.1 BrnT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3418966..3429083 10117


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6976.17 Da        Isoelectric Point: 10.9763

>T28611 WP_015227169.1 NC_019779:c3421162-3420974 [Halothece sp. PCC 7418]
MKVKEIIRLIENDGWKLARTKGSHRQYKHPTKRGLVTIPGKPNDDIAPGTENSILKQAGIKK

Download         Length: 189 bp

>T28611 NC_019779:c3421162-3420974 [Halothece sp. PCC 7418]
ATGAAAGTTAAAGAGATTATCCGCCTTATTGAAAATGATGGGTGGAAACTTGCCAGAACTAAAGGCAGTCATCGTCAGTA
TAAACACCCGACTAAACGGGGCTTAGTCACTATCCCAGGTAAACCTAACGACGATATCGCTCCTGGAACTGAGAATAGTA
TCTTAAAACAAGCTGGAATCAAAAAATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7906.00 Da        Isoelectric Point: 4.1933

>AT28611 WP_015227168.1 NC_019779:c3420952-3420737 [Halothece sp. PCC 7418]
MNRYLIVIEKTSTGYSAYSPDLLGCVSTGTTIEEVKENMKEAIQFHLEGMKEEGYEIPLPTTTSSFLEVAI

Download         Length: 216 bp

>AT28611 NC_019779:c3420952-3420737 [Halothece sp. PCC 7418]
ATGAACAGATATTTAATTGTAATTGAAAAAACATCAACGGGATATTCTGCCTATTCTCCAGATTTGCTAGGCTGCGTCTC
CACAGGTACAACAATCGAGGAAGTGAAAGAGAATATGAAAGAAGCGATACAGTTTCATCTCGAAGGGATGAAAGAAGAGG
GCTATGAAATTCCATTGCCAACAACCACTTCTTCATTTTTAGAAGTTGCCATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K9YFN2

Antitoxin

Source ID Structure
AlphaFold DB K9YEB2

References