Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 3420737..3421162 Replicon chromosome
Accession NC_019779
Organism Halothece sp. PCC 7418 (Aphanothece halophytica 7418)

Toxin (Protein)


Gene name hicA Uniprot ID K9YFN2
Locus tag PCC7418_RS15690 Protein ID WP_015227169.1
Coordinates 3420974..3421162 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID K9YEB2
Locus tag PCC7418_RS15685 Protein ID WP_015227168.1
Coordinates 3420737..3420952 (-) Length 72 a.a.

Genomic Context

PCC7418_RS15660PCC7418_RS15665PCC7418_RS15670PCC7418_RS15675PCC7418_RS15680PCC7418_RS15685PCC7418_RS15690PCC7418_RS15695PCC7418_RS15700PCC7418_RS15705PCC7418_RS15710
Location: 3416483..3417631 (1149 bp)
Type: Others
Protein ID: WP_015227162.1
Location: 3417652..3418833 (1182 bp)
Type: Others
Protein ID: WP_015227163.1
Location: 3418966..3419697 (732 bp)
Type: Others
Protein ID: WP_015227164.1
Location: 3420053..3420316 (264 bp)
Type: Others
Protein ID: WP_015227166.1
Location: 3420313..3420537 (225 bp)
Type: Others
Protein ID: WP_015227167.1
Location: 3420737..3420952 (216 bp)
Type: Antitoxin
Protein ID: WP_015227168.1
Location: 3420974..3421162 (189 bp)
Type: Toxin
Protein ID: WP_015227169.1
Location: 3421293..3421568 (276 bp)
Type: Others
Protein ID: WP_015227170.1
Location: 3422035..3422688 (654 bp)
Type: Others
Protein ID: WP_015227171.1
Location: 3422786..3423070 (285 bp)
Type: Others
Protein ID: WP_015227172.1
Location: 3423060..3423356 (297 bp)
Type: Others
Protein ID: WP_015227173.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PCC7418_RS156603416483..3417631+1149WP_015227162.1iron-containing alcohol dehydrogenase family protein-
PCC7418_RS156653417652..3418833+1182WP_015227163.1aspartate aminotransferase-
PCC7418_RS156703418966..3419697+732WP_015227164.1class I SAM-dependent methyltransferase-
PCC7418_RS156753420053..3420316-264WP_015227166.1type II toxin-antitoxin system RelE/ParE family toxin-
PCC7418_RS156803420313..3420537-225WP_015227167.1hypothetical protein-
PCC7418_RS156853420737..3420952-216WP_015227168.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
PCC7418_RS156903420974..3421162-189WP_015227169.1type II toxin-antitoxin system HicA family toxinToxin
PCC7418_RS156953421293..3421568-276WP_015227170.1hypothetical protein-
PCC7418_RS157003422035..3422688-654WP_015227171.1GIY-YIG nuclease family protein-
PCC7418_RS157053422786..3423070-285WP_015227172.1hypothetical protein-
PCC7418_RS157103423060..3423356-297WP_015227173.1BrnT family toxin-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--3418966..342908310117


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6976.17 Da        Isoelectric Point: 10.9763

>T28611 WP_015227169.1 NC_019779:c3421162-3420974 [Halothece sp. PCC 7418]
MKVKEIIRLIENDGWKLARTKGSHRQYKHPTKRGLVTIPGKPNDDIAPGTENSILKQAGIKK

Download         Length: 189 bp

>T28611 NC_019779:c3421162-3420974 [Halothece sp. PCC 7418]
ATGAAAGTTAAAGAGATTATCCGCCTTATTGAAAATGATGGGTGGAAACTTGCCAGAACTAAAGGCAGTCATCGTCAGTA
TAAACACCCGACTAAACGGGGCTTAGTCACTATCCCAGGTAAACCTAACGACGATATCGCTCCTGGAACTGAGAATAGTA
TCTTAAAACAAGCTGGAATCAAAAAATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7906.00 Da        Isoelectric Point: 4.1933

>AT28611 WP_015227168.1 NC_019779:c3420952-3420737 [Halothece sp. PCC 7418]
MNRYLIVIEKTSTGYSAYSPDLLGCVSTGTTIEEVKENMKEAIQFHLEGMKEEGYEIPLPTTTSSFLEVAI

Download         Length: 216 bp

>AT28611 NC_019779:c3420952-3420737 [Halothece sp. PCC 7418]
ATGAACAGATATTTAATTGTAATTGAAAAAACATCAACGGGATATTCTGCCTATTCTCCAGATTTGCTAGGCTGCGTCTC
CACAGGTACAACAATCGAGGAAGTGAAAGAGAATATGAAAGAAGCGATACAGTTTCATCTCGAAGGGATGAAAGAAGAGG
GCTATGAAATTCCATTGCCAACAACCACTTCTTCATTTTTAGAAGTTGCCATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBK9YFN2

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBK9YEB2

References