Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1033188..1033686 Replicon chromosome
Accession NZ_LR129841
Organism Streptococcus pneumoniae strain 947 isolate 947

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EQB42_RS05475 Protein ID WP_001812387.1
Coordinates 1033432..1033686 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQB42_RS05470 Protein ID WP_000208080.1
Coordinates 1033188..1033430 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB42_RS05450 1029010..1030185 + 1176 WP_000886147.1 A/G-specific adenine glycosylase -
EQB42_RS05455 1030240..1030944 + 705 WP_000722076.1 response regulator transcription factor -
EQB42_RS05460 1030937..1032286 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQB42_RS05465 1032288..1033097 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQB42_RS05470 1033188..1033430 + 243 WP_000208080.1 hypothetical protein Antitoxin
EQB42_RS05475 1033432..1033686 + 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQB42_RS05480 1033733..1034385 + 653 Protein_1017 potassium channel family protein -
EQB42_RS05485 1034645..1035631 - 987 WP_000204727.1 L-lactate dehydrogenase -
EQB42_RS05490 1035825..1038293 + 2469 WP_001152992.1 DNA gyrase subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.85 Da        Isoelectric Point: 10.7632

>T286108 WP_001812387.1 NZ_LR129841:1033432-1033686 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT286108 WP_000208080.1 NZ_LR129841:1033188-1033430 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References