Detailed information of TA system TA286107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 981907..983144
• Replicon: chromosome
• Accession: NZ_LR129841
• Organism: Streptococcus pneumoniae strain 947 isolate 947

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A098ZIW8
• Locus tag: EQB42_RS05220
• Protein ID: WP_000405362.1
• Coordinates: 982383..983144 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: EQB42_RS05215
• Protein ID: WP_000579613.1
• Coordinates: 981907..982383 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQB42_RS05195	976980..977834	+	855	WP_000900020.1	ADP-ribosylglycohydrolase family protein	-
EQB42_RS05200	977946..978830	+	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
EQB42_RS05205	978993..980732	+	1740	Protein_963	alpha-glycosidase	-
EQB42_RS05210	981007..981462	+	456	WP_000500474.1	hypothetical protein	-
EQB42_RS05215	981907..982383	+	477	WP_000579613.1	helix-turn-helix domain-containing protein	Antitoxin
EQB42_RS05220	982383..983144	+	762	WP_000405362.1	toxin PezT	Toxin
EQB42_RS05225	983172..983948	+	777	Protein_967	hypothetical protein	-
EQB42_RS05230	983876..984328	+	453	WP_001808559.1	hypothetical protein	-
EQB42_RS05235	985147..985506	+	360	WP_000003745.1	hypothetical protein	-
EQB42_RS05240	985516..985881	+	366	WP_000263048.1	MobC family plasmid mobilization relaxosome protein	-
EQB42_RS05245	985868..987718	+	1851	WP_000261804.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	963441..989406	25965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29129.16 Da
• Isoelectric Point: 7.1308

>T286107 WP_000405362.1 NZ_LR129841:982383-983144 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18249.67 Da
• Isoelectric Point: 4.3462

>AT286107 WP_000579613.1 NZ_LR129841:981907-982383 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A098ZIW8