Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1707241..1707903 Replicon chromosome
Accession NZ_LR129840
Organism Streptococcus pneumoniae strain 4496 isolate 4496

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EQB41_RS09115 Protein ID WP_000192221.1
Coordinates 1707730..1707903 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQB41_RS09110 Protein ID WP_000961810.1
Coordinates 1707241..1707693 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB41_RS09090 1704090..1705124 - 1035 WP_000747916.1 ATP-binding protein -
EQB41_RS09095 1705234..1705392 - 159 WP_000418159.1 7,8-dihydro-8-oxoguanine-triphosphatase -
EQB41_RS09100 1705373..1706461 - 1089 WP_000719711.1 M50 family metallopeptidase -
EQB41_RS09105 1706480..1706950 - 471 WP_000257085.1 DUF3013 family protein -
EQB41_RS09110 1707241..1707693 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQB41_RS09115 1707730..1707903 - 174 WP_000192221.1 type II toxin-antitoxin system HicA family toxin Toxin
EQB41_RS09120 1708046..1708294 - 249 WP_000797237.1 hypothetical protein -
EQB41_RS09125 1708284..1708523 - 240 WP_000818079.1 hypothetical protein -
EQB41_RS09135 1708793..1710064 + 1272 WP_127820839.1 replication-associated recombination protein A -
EQB41_RS09145 1710609..1711928 - 1320 WP_000502561.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6368.47 Da        Isoelectric Point: 10.8214

>T286106 WP_000192221.1 NZ_LR129840:c1707903-1707730 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 174 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT286106 WP_000961810.1 NZ_LR129840:c1707693-1707241 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References