Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1202574..1203072 Replicon chromosome
Accession NZ_LR129840
Organism Streptococcus pneumoniae strain 4496 isolate 4496

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag EQB41_RS06440 Protein ID WP_001823540.1
Coordinates 1202574..1202828 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQB41_RS06445 Protein ID WP_000208080.1
Coordinates 1202830..1203072 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB41_RS06425 1197846..1200314 - 2469 WP_001152988.1 DNA gyrase subunit A -
EQB41_RS06430 1200508..1201494 + 987 WP_000204727.1 L-lactate dehydrogenase -
EQB41_RS06435 1201784..1202527 - 744 WP_000725952.1 ion transporter -
EQB41_RS06440 1202574..1202828 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQB41_RS06445 1202830..1203072 - 243 WP_000208080.1 hypothetical protein Antitoxin
EQB41_RS06450 1203163..1203972 - 810 WP_001289496.1 MBL fold metallo-hydrolase -
EQB41_RS06455 1203974..1205323 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQB41_RS06460 1205316..1206020 - 705 WP_000722076.1 response regulator transcription factor -
EQB41_RS06465 1206075..1207250 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T286105 WP_001823540.1 NZ_LR129840:c1202828-1202574 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT286105 WP_000208080.1 NZ_LR129840:c1203072-1202830 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References