Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 1067778..1069024 Replicon chromosome
Accession NZ_LR129840
Organism Streptococcus pneumoniae strain 4496 isolate 4496

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag EQB41_RS05800 Protein ID WP_016399580.1
Coordinates 1067778..1068548 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag EQB41_RS05805 Protein ID WP_000579623.1
Coordinates 1068548..1069024 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB41_RS05770 1063758..1064123 - 366 WP_000401236.1 plasmid mobilization relaxosome protein MobC -
EQB41_RS05775 1064128..1064484 - 357 WP_000827835.1 hypothetical protein -
EQB41_RS05780 1064779..1065069 - 291 WP_001080184.1 hypothetical protein -
EQB41_RS05785 1065059..1065424 - 366 WP_000981955.1 hypothetical protein -
EQB41_RS05790 1065421..1066836 - 1416 WP_000118333.1 Y-family DNA polymerase -
EQB41_RS05795 1066839..1067522 - 684 WP_000492698.1 LexA family transcriptional regulator -
EQB41_RS05800 1067778..1068548 - 771 WP_016399580.1 zeta toxin family protein Toxin
EQB41_RS05805 1068548..1069024 - 477 WP_000579623.1 helix-turn-helix domain-containing protein Antitoxin
EQB41_RS05810 1069092..1069364 - 273 WP_000495438.1 hypothetical protein -
EQB41_RS05815 1069402..1069785 - 384 WP_000159212.1 hypothetical protein -
EQB41_RS05820 1069782..1070015 - 234 WP_000152419.1 hypothetical protein -
EQB41_RS05825 1070066..1071151 - 1086 WP_050215984.1 toprim domain-containing protein -
EQB41_RS05830 1071161..1071802 - 642 WP_050215983.1 hypothetical protein -
EQB41_RS05835 1071962..1072159 + 198 WP_004249782.1 hypothetical protein -
EQB41_RS05840 1072173..1072469 - 297 WP_000998891.1 hypothetical protein -
EQB41_RS05845 1072483..1072767 - 285 WP_000969641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 959773..1085522 125749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29342.32 Da        Isoelectric Point: 7.9440

>T286104 WP_016399580.1 NZ_LR129840:c1068548-1067778 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTNRNGC

Download         Length: 771 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18259.71 Da        Isoelectric Point: 4.4258

>AT286104 WP_000579623.1 NZ_LR129840:c1069024-1068548 [Streptococcus pneumoniae]
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References