Detailed information of TA system TA286103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): zeta-pezA/zeta-couple_hipB
• Location: 977390..978627
• Replicon: chromosome
• Accession: NZ_LR129840
• Organism: Streptococcus pneumoniae strain 4496 isolate 4496

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: EQB41_RS05345
• Protein ID: WP_127820773.1
• Coordinates: 977866..978627 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: B6ZCC4
• Locus tag: EQB41_RS05340
• Protein ID: WP_000579612.1
• Coordinates: 977390..977866 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQB41_RS05320	972466..973320	+	855	WP_000900020.1	ADP-ribosylglycohydrolase family protein	-
EQB41_RS05325	973432..974316	+	885	WP_000710109.1	diacylglycerol kinase family lipid kinase	-
EQB41_RS05330	974479..976222	+	1744	Protein_994	alpha-glycosidase	-
EQB41_RS05335	976490..976945	+	456	WP_050245894.1	hypothetical protein	-
EQB41_RS05340	977390..977866	+	477	WP_000579612.1	helix-turn-helix domain-containing protein	Antitoxin
EQB41_RS05345	977866..978627	+	762	WP_127820773.1	zeta toxin family protein	Toxin
EQB41_RS05350	978655..979812	+	1158	WP_001213953.1	hypothetical protein	-
EQB41_RS05355	980631..980990	+	360	WP_000003746.1	hypothetical protein	-
EQB41_RS05360	981066..981364	+	299	Protein_1000	MobC family plasmid mobilization relaxosome protein	-
EQB41_RS12065	981351..983216	+	1866	Protein_1001	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	959773..1085522	125749

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29054.01 Da
• Isoelectric Point: 6.7039

>T286103 WP_127820773.1 NZ_LR129840:977866-978627 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKETAQLLKSKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
RVGEKRLNELLEK

Nucleotide

• Length: 762 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18245.68 Da
• Isoelectric Point: 4.4188

>AT286103 WP_000579612.1 NZ_LR129840:977390-977866 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Antitoxin

• AlphaFold DB: B6ZCC4