Detailed information of TA system TA028610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1642745..1643382
• Replicon: chromosome
• Accession: NC_019779
• Organism: Halothece sp. PCC 7418 (Aphanothece halophytica 7418)

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K9Y9T1
• Locus tag: PCC7418_RS07430
• Protein ID: WP_015225562.1
• Coordinates: 1642745..1643155 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K9YB59
• Locus tag: PCC7418_RS07435
• Protein ID: WP_015225563.1
• Coordinates: 1643152..1643382 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCC7418_RS07410	1638263..1639504	-	1242	WP_150107131.1	class I SAM-dependent RNA methyltransferase	-
PCC7418_RS07415	1639562..1640257	-	696	WP_015225559.1	ribulose-phosphate 3-epimerase	-
PCC7418_RS07420	1640344..1641939	+	1596	WP_015225560.1	S8 family serine peptidase	-
PCC7418_RS07425	1641906..1642712	-	807	WP_015225561.1	SWIM zinc finger family protein	-
PCC7418_RS07430	1642745..1643155	-	411	WP_015225562.1	type II toxin-antitoxin system VapC family toxin	Toxin
PCC7418_RS07435	1643152..1643382	-	231	WP_015225563.1	DUF2281 domain-containing protein	Antitoxin
PCC7418_RS07440	1643574..1645244	-	1671	WP_015225564.1	chaperonin GroEL	-
PCC7418_RS07445	1645342..1647123	-	1782	WP_015225565.1	glycosyltransferase family 39 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-136)

Antitoxin

• Domain of unknown function DUF2281 (6-74)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15608.08 Da
• Isoelectric Point: 6.6468

>T28610 WP_015225562.1 NC_019779:c1643155-1642745 [Halothece sp. PCC 7418]
MSAFLLDTHAFIWLSEDDPNLPESLREKIDKADVVYVSIASLWEIAIKLNLGKLSLKRNYEIIGIEVESSDIILLPISFR
DTALIRHLPLHHRDPFDRMLVAQAMNHSLIIASRDRAKLAGRANRAFDAYSIERIW

Nucleotide

• Length: 411 bp

>T28610 NC_019779:c1643155-1642745 [Halothece sp. PCC 7418]
ATGAGTGCTTTTCTATTAGACACTCACGCTTTTATTTGGCTGTCGGAAGATGACCCAAATTTACCAGAATCCCTCAGAGA
GAAGATTGATAAAGCTGATGTTGTATATGTTAGCATCGCAAGTTTATGGGAGATTGCGATTAAGTTAAACTTGGGAAAGT
TATCTCTAAAACGAAATTATGAAATCATTGGTATTGAAGTTGAATCTTCTGACATTATTTTACTTCCTATTTCATTTCGT
GATACAGCTTTAATTCGCCACTTACCTTTACACCATCGAGATCCATTTGATCGAATGTTAGTTGCACAAGCAATGAATCA
TTCTTTAATTATAGCTAGTCGCGATCGAGCGAAGCTCGCTGGCAGAGCCAATCGCGCTTTTGATGCTTATTCAATAGAAA
GAATTTGGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9052.27 Da
• Isoelectric Point: 4.6388

>AT28610 WP_015225563.1 NC_019779:c1643382-1643152 [Halothece sp. PCC 7418]
MNTDLELWQAISKMPEHLKTEFLNYAEYLMEKKANTTHSDQNLEKKRRSGILKGTFVLPLPKDFDEPLEDFQDYME

Nucleotide

• Length: 231 bp

>AT28610 NC_019779:c1643382-1643152 [Halothece sp. PCC 7418]
ATGAATACTGATCTCGAACTCTGGCAAGCAATTAGCAAAATGCCTGAACATTTAAAGACTGAATTTTTGAATTATGCAGA
ATATTTAATGGAGAAAAAAGCAAACACAACTCACTCGGATCAAAACTTAGAAAAAAAACGGCGATCTGGAATTTTGAAAG
GAACTTTTGTCTTACCATTACCAAAAGACTTTGATGAACCATTAGAAGATTTTCAGGATTATATGGAATGA

Structures

Toxin

• AlphaFold DB: K9Y9T1

Antitoxin

• AlphaFold DB: K9YB59