Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2346928..2347457 Replicon chromosome
Accession NZ_LR027878
Organism Staphylococcus aureus strain BPH2003 isolate BPH2003

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E0E10_RS12465 Protein ID WP_000621175.1
Coordinates 2346928..2347290 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E0E10_RS12470 Protein ID WP_000948331.1
Coordinates 2347287..2347457 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E10_RS12440 2343908..2344678 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
E0E10_RS12445 2344653..2345132 - 480 WP_001190829.1 anti-sigma B factor RsbW -
E0E10_RS12450 2345134..2345460 - 327 WP_001052491.1 anti-sigma factor antagonist -
E0E10_RS12455 2345578..2346579 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E0E10_RS12465 2346928..2347290 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E0E10_RS12470 2347287..2347457 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E0E10_RS12475 2347542..2348690 - 1149 WP_001281145.1 alanine racemase -
E0E10_RS12480 2348756..2349115 - 360 WP_000581200.1 holo-ACP synthase -
E0E10_RS12485 2349119..2349610 - 492 WP_001205910.1 PH domain-containing protein -
E0E10_RS12490 2349597..2351180 - 1584 WP_001294626.1 PH domain-containing protein -
E0E10_RS12495 2351173..2351652 - 480 WP_001287088.1 hypothetical protein -
E0E10_RS12500 2351860..2352420 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286093 WP_000621175.1 NZ_LR027878:c2347290-2346928 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286093 WP_000948331.1 NZ_LR027878:c2347457-2347287 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References