Detailed information of TA system TA028609

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1186197..1186834
• Replicon: chromosome
• Accession: NC_019779
• Organism: Halothece sp. PCC 7418 (Aphanothece halophytica 7418)

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K9Y8M6
• Locus tag: PCC7418_RS05430
• Protein ID: WP_015225168.1
• Coordinates: 1186197..1186601 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: PCC7418_RS05435
• Protein ID: WP_041596154.1
• Coordinates: 1186601..1186834 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCC7418_RS05410	1182434..1182844	+	411	WP_150107126.1	IS200/IS605 family transposase	-
PCC7418_RS05415	1182983..1183846	+	864	WP_015225165.1	Tab2/Atab2 family RNA-binding protein	-
PCC7418_RS05420	1183843..1185123	+	1281	WP_015225166.1	TldD/PmbA family protein	-
PCC7418_RS05425	1185120..1186133	-	1014	WP_015225167.1	glycerate kinase	-
PCC7418_RS05430	1186197..1186601	-	405	WP_015225168.1	type II toxin-antitoxin system VapC family toxin	Toxin
PCC7418_RS05435	1186601..1186834	-	234	WP_041596154.1	hypothetical protein	Antitoxin
PCC7418_RS05440	1186956..1188872	-	1917	WP_015225170.1	1-deoxy-D-xylulose-5-phosphate synthase	-
PCC7418_RS05445	1189086..1190075	+	990	WP_015225171.1	ABC transporter ATP-binding protein	-
PCC7418_RS05450	1190281..1191507	+	1227	WP_015225172.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15439.14 Da
• Isoelectric Point: 4.9009

>T28609 WP_015225168.1 NC_019779:c1186601-1186197 [Halothece sp. PCC 7418]
MKVLLDTNICIYIIKKQPPSVLERLQDYQVGEICISTITLYELMYGVYKSQLLEVNRQAIRQFVSPLEVLPFDEGAADWC
GYIRAILEQEGKIIGPMDLQIAAIALSYSLTLITNNEKEFKRIKQLNVENWIKL

Nucleotide

• Length: 405 bp

>T28609 NC_019779:c1186601-1186197 [Halothece sp. PCC 7418]
ATGAAAGTTTTATTAGACACTAATATCTGCATCTACATTATCAAAAAGCAACCTCCATCTGTGCTAGAACGACTCCAAGA
CTATCAAGTTGGAGAGATTTGTATATCAACGATTACTCTTTATGAATTGATGTATGGGGTTTATAAAAGTCAACTTTTGG
AGGTCAATCGACAAGCAATCCGTCAGTTTGTTTCTCCTCTGGAAGTTTTACCGTTTGATGAAGGTGCTGCCGATTGGTGT
GGCTATATCCGCGCGATCTTAGAACAAGAAGGAAAAATCATTGGACCGATGGATTTACAAATTGCTGCTATAGCACTTTC
ATATAGTTTAACTTTGATCACTAATAATGAAAAAGAATTTAAACGGATTAAGCAGTTAAATGTAGAAAACTGGATTAAAT
TGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9202.34 Da
• Isoelectric Point: 4.6677

>AT28609 WP_041596154.1 NC_019779:c1186834-1186601 [Halothece sp. PCC 7418]
MQYTRLSKHGYSQEVRIPRDYRLSGKRVKISRYGRGLLIEPVSEGFDDLLDSLELFSEDFLEERPEQLPFDTREDMF

Nucleotide

• Length: 234 bp

>AT28609 NC_019779:c1186834-1186601 [Halothece sp. PCC 7418]
ATGCAATATACACGTCTTTCTAAGCATGGGTATTCCCAAGAAGTTAGAATTCCACGAGATTATCGACTTTCTGGAAAGCG
AGTGAAAATTTCTCGATATGGGAGAGGACTTCTCATTGAACCTGTCTCGGAGGGGTTTGATGACCTGCTGGATTCACTAG
AGTTATTTTCAGAAGATTTTCTGGAAGAACGTCCCGAACAACTTCCTTTTGATACTAGGGAAGATATGTTTTGA

Structures

Toxin

• AlphaFold DB: K9Y8M6