Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 942245..942722 Replicon chromosome
Accession NZ_LR027878
Organism Staphylococcus aureus strain BPH2003 isolate BPH2003

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag E0E10_RS04880 Protein ID WP_000052078.1
Coordinates 942245..942433 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E0E10_RS04885 Protein ID WP_001059690.1
Coordinates 942462..942722 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E10_RS04850 938285..938755 + 471 WP_000824472.1 hypothetical protein -
E0E10_RS04855 939096..939782 + 687 WP_001548082.1 thermonuclease family protein -
E0E10_RS04860 940139..940339 + 201 WP_001059082.1 cold-shock protein -
E0E10_RS04865 940836..941054 - 219 WP_000005886.1 hypothetical protein -
E0E10_RS04870 941116..941400 - 285 WP_001004395.1 hypothetical protein -
E0E10_RS04875 941488..942057 - 570 WP_001106654.1 hypothetical protein -
E0E10_RS04880 942245..942433 - 189 WP_000052078.1 hypothetical protein Toxin
E0E10_RS04885 942462..942722 - 261 WP_001059690.1 hypothetical protein Antitoxin
E0E10_RS04890 943063..943266 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E0E10_RS04895 943263..943499 - 237 WP_000368687.1 hypothetical protein -
E0E10_RS04900 943724..944305 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
E0E10_RS04905 944378..944995 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
E0E10_RS04910 945150..945644 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E0E10_RS04915 946043..946465 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
E0E10_RS04920 946613..947329 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 936928..966990 30062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T286085 WP_000052078.1 NZ_LR027878:c942433-942245 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT286085 WP_001059690.1 NZ_LR027878:c942722-942462 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References