Detailed information of TA system TA028608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 866909..867425
• Replicon: chromosome
• Accession: NC_019779
• Organism: Halothece sp. PCC 7418 (Aphanothece halophytica 7418)

Toxin (Protein)

• Gene name: relB
• Uniprot ID: K9YA58
• Locus tag: PCC7418_RS03940
• Protein ID: WP_015224881.1
• Coordinates: 866909..867172 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: K9Y836
• Locus tag: PCC7418_RS03945
• Protein ID: WP_015224882.1
• Coordinates: 867165..867425 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCC7418_RS20410	862608..862766	-	159	WP_171814881.1	hypothetical protein	-
PCC7418_RS20050	863058..863938	+	881	Protein_770	hypothetical protein	-
PCC7418_RS03900	864023..864249	+	227	Protein_771	type II toxin-antitoxin system HicA family toxin	-
PCC7418_RS03905	864246..864464	+	219	WP_015224874.1	type II toxin-antitoxin system HicB family antitoxin	-
PCC7418_RS20415	864479..864616	+	138	WP_171814882.1	hypothetical protein	-
PCC7418_RS03910	864678..864917	-	240	WP_015224875.1	type II toxin-antitoxin system HicB family antitoxin	-
PCC7418_RS03915	864908..865153	-	246	WP_015224876.1	type II toxin-antitoxin system HicA family toxin	-
PCC7418_RS03920	865449..865724	-	276	WP_015224877.1	helix-turn-helix domain-containing protein	-
PCC7418_RS03925	865721..866047	-	327	WP_015224878.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PCC7418_RS03930	866244..866450	-	207	WP_015224879.1	hypothetical protein	-
PCC7418_RS03935	866450..866743	-	294	WP_015224880.1	BrnT family toxin	-
PCC7418_RS03940	866909..867172	-	264	WP_015224881.1	Txe/YoeB family addiction module toxin	Toxin
PCC7418_RS03945	867165..867425	-	261	WP_015224882.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PCC7418_RS03950	867773..868072	+	300	WP_150107119.1	nucleotidyltransferase family protein	-
PCC7418_RS03955	868056..868418	+	363	WP_015224884.1	DUF86 domain-containing protein	-
PCC7418_RS03960	868510..869649	-	1140	WP_015224885.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	866244..879039	12795

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-76)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10529.94 Da
• Isoelectric Point: 9.3453

>T28608 WP_015224881.1 NC_019779:c867172-866909 [Halothece sp. PCC 7418]
MRKLAWSSKAWKDYLYWQSQDKKTLKRINRLIEDALSNPFEGIGKPEPLRENLSGFWSRRIDETNRLVYAVDDNYLTILS
CRYHYQE

Nucleotide

• Length: 264 bp

>T28608 NC_019779:c867172-866909 [Halothece sp. PCC 7418]
ATGCGTAAATTAGCTTGGAGTAGTAAAGCATGGAAAGACTATCTTTATTGGCAATCTCAAGATAAAAAGACTCTAAAAAG
AATCAATCGATTAATCGAAGATGCTTTATCTAACCCCTTTGAAGGAATCGGAAAACCTGAACCCTTAAGAGAGAATTTAT
CAGGTTTTTGGTCTCGTCGTATTGATGAAACCAATCGTCTTGTTTATGCTGTTGATGATAATTATTTGACCATTCTTTCC
TGTCGGTATCATTACCAAGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9641.81 Da
• Isoelectric Point: 4.5368

>AT28608 WP_015224882.1 NC_019779:c867425-867165 [Halothece sp. PCC 7418]
MNMNIVNFSEARKNFKSVLDTVANDKNCTVIVRRDAEDAVVMSKSYYDSLMETVYLLNSPANAQHLEAAIAEYKAGQTQE
HDLIDA

Nucleotide

• Length: 261 bp

>AT28608 NC_019779:c867425-867165 [Halothece sp. PCC 7418]
ATGAACATGAACATTGTCAACTTTAGCGAAGCGAGAAAAAACTTCAAATCTGTACTTGATACAGTAGCCAACGACAAAAA
TTGTACTGTTATCGTCAGGAGAGATGCAGAAGATGCAGTTGTCATGTCTAAAAGTTATTATGACAGCCTAATGGAAACAG
TTTACCTATTAAACTCTCCTGCTAATGCTCAACATTTAGAAGCAGCGATCGCCGAATATAAAGCAGGGCAAACACAAGAA
CATGATTTAATTGATGCGTAA

Structures

Toxin

• AlphaFold DB: K9YA58

Antitoxin

• AlphaFold DB: K9Y836