Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1963017..1963793 Replicon chromosome
Accession NZ_LR027877
Organism Staphylococcus aureus isolate BPH3244

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag E0E14_RS09935 Protein ID WP_000031108.1
Coordinates 1963017..1963169 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag E0E14_RS09940 Protein ID WP_001251224.1
Coordinates 1963194..1963793 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E14_RS09910 1958980..1959801 + 822 WP_000669375.1 RluA family pseudouridine synthase -
E0E14_RS09915 1960264..1961649 - 1386 WP_000116224.1 class II fumarate hydratase -
E0E14_RS09920 1961845..1962240 - 396 WP_000901021.1 hypothetical protein -
E0E14_RS09935 1963017..1963169 - 153 WP_000031108.1 hypothetical protein Toxin
E0E14_RS09940 1963194..1963793 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
E0E14_RS09945 1963952..1964422 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E0E14_RS09950 1964427..1965554 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
E0E14_RS09955 1965705..1966427 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
E0E14_RS09960 1966420..1967877 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1915597..1971050 55453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T286072 WP_000031108.1 NZ_LR027877:c1963169-1963017 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT286072 WP_001251224.1 NZ_LR027877:c1963793-1963194 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References