Detailed information of TA system TA028607

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 783231..784099
• Replicon: chromosome
• Accession: NC_019779
• Organism: Halothece sp. PCC 7418 (Aphanothece halophytica 7418)

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: PCC7418_RS03505
• Protein ID: WP_015224795.1
• Coordinates: 783231..783683 (-)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: K9Y9X3
• Locus tag: PCC7418_RS03510
• Protein ID: WP_015224796.1
• Coordinates: 783680..784099 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCC7418_RS03495	778812..779825	-	1014	WP_015224793.1	type I-D CRISPR-associated protein Cas7/Csc2	-
PCC7418_RS03500	779927..783238	-	3312	WP_015224794.1	type I-D CRISPR-associated protein Cas10d/Csc3	-
PCC7418_RS03505	783231..783683	-	453	WP_015224795.1	DUF86 domain-containing protein	Toxin
PCC7418_RS03510	783680..784099	-	420	WP_015224796.1	nucleotidyltransferase domain-containing protein	Antitoxin
PCC7418_RS03515	784558..784737	-	180	Protein_691	hypothetical protein	-
PCC7418_RS20400	784864..785016	-	153	WP_015224798.1	hypothetical protein	-
PCC7418_RS03520	785004..787250	-	2247	WP_015224799.1	type I-D CRISPR-associated helicase Cas3'	-
PCC7418_RS03525	787322..787480	-	159	Protein_694	DNA polymerase subunit beta	-
PCC7418_RS03530	787672..788520	+	849	WP_015224800.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (16-131)

Antitoxin

• Polymerase beta, nucleotidyltransferase (16-103)

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 17688.37 Da
• Isoelectric Point: 4.7245

>T28607 WP_015224795.1 NC_019779:c783683-783231 [Halothece sp. PCC 7418]
MSQIEPEVILARLQAIRKYLQRLKQFESLTFEEYQNNFDTQLVTERLVQLCTEAALDINKYLFAKLGLITSKHELTNKEY
FLNAIAHDILTKETGKTLANAAGMRNILVHLYLDIENYQVFLAIEKCLKYYPVYMREILDYIDQLEEEND

Nucleotide

• Length: 453 bp

>T28607 NC_019779:c783683-783231 [Halothece sp. PCC 7418]
ATGAGTCAGATCGAACCAGAAGTTATCTTAGCACGGTTACAAGCGATTCGGAAGTATCTTCAGCGTCTTAAGCAGTTTGA
GTCGTTGACATTTGAAGAGTATCAGAATAATTTTGATACTCAACTGGTCACTGAAAGACTGGTGCAACTTTGTACGGAAG
CAGCCTTAGATATTAACAAGTATTTGTTTGCAAAATTAGGATTGATTACCAGCAAGCATGAGTTGACAAATAAAGAGTAT
TTTCTAAACGCGATCGCGCACGATATCTTAACAAAAGAAACAGGGAAAACCTTAGCCAATGCAGCAGGAATGAGAAATAT
CTTAGTTCATTTGTATCTAGATATTGAAAATTATCAAGTCTTTTTAGCGATTGAGAAGTGCTTAAAATACTATCCCGTTT
ATATGCGCGAAATTCTCGATTATATTGATCAATTAGAGGAAGAAAATGACTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 16403.69 Da
• Isoelectric Point: 5.2587

>AT28607 WP_015224796.1 NC_019779:c784099-783680 [Halothece sp. PCC 7418]
MNHLSKQFSPFIPQVTYLKMLVIFGSRGRGEAHKKSDWDFAVLYDEKLEKEQLKGWNWLKIYDVLANAFEISSDAIDVIN
LNHCSPLIAHYVARDGQLIYEQETGLFEQFKTENFMNQEELKSLRQVMRREIEEFLQNA

Nucleotide

• Length: 420 bp

>AT28607 NC_019779:c784099-783680 [Halothece sp. PCC 7418]
ATGAATCACTTATCAAAACAATTTTCTCCATTTATTCCGCAAGTTACTTATCTGAAAATGCTAGTTATTTTTGGTTCTAG
AGGGAGAGGAGAAGCCCATAAAAAGAGCGATTGGGATTTTGCTGTACTCTATGATGAAAAGTTAGAAAAAGAACAGTTGA
AAGGTTGGAATTGGTTGAAAATTTATGATGTTTTAGCAAATGCGTTTGAGATTTCTAGTGACGCGATCGATGTGATTAAT
CTCAACCACTGTTCTCCGTTAATTGCTCATTATGTCGCCCGTGATGGTCAATTAATCTATGAACAGGAAACTGGACTCTT
TGAACAGTTTAAGACTGAAAATTTCATGAATCAAGAAGAATTAAAATCCCTGCGTCAAGTGATGCGACGAGAAATTGAAG
AGTTCTTACAAAACGCATGA

Structures

Antitoxin

• AlphaFold DB: K9Y9X3