Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2243349..2243863 Replicon chromosome
Accession NZ_LR027876
Organism Staphylococcus aureus strain JKD6009 isolate JKD6009

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E0E12_RS11860 Protein ID WP_000581792.1
Coordinates 2243349..2243558 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E0E12_RS11865 Protein ID WP_000138932.1
Coordinates 2243570..2243863 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E12_RS11840 2238857..2240215 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E0E12_RS11845 2240230..2241300 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E0E12_RS11850 2241618..2242820 + 1203 WP_001109937.1 rod shape-determining protein RodA -
E0E12_RS11855 2243084..2243221 - 138 WP_000828354.1 hypothetical protein -
E0E12_RS11860 2243349..2243558 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E0E12_RS11865 2243570..2243863 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E0E12_RS11870 2244029..2245513 + 1485 WP_000571549.1 cardiolipin synthase -
E0E12_RS11875 2245541..2246188 + 648 WP_001187629.1 HD domain-containing protein -
E0E12_RS11895 2247001..2247873 - 873 WP_000725802.1 membrane protein insertase YidC -
E0E12_RS11900 2247959..2248600 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T286060 WP_000581792.1 NZ_LR027876:c2243558-2243349 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT286060 WP_000138932.1 NZ_LR027876:c2243863-2243570 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References