Detailed information of TA system TA028604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1956869..1957386
• Replicon: chromosome
• Accession: NC_019776
• Organism: Cyanobacterium aponinum PCC 10605

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K9Z5T7
• Locus tag: CYAN10605_RS08150
• Protein ID: WP_015219465.1
• Coordinates: 1957132..1957386 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: K9Z4T8
• Locus tag: CYAN10605_RS08145
• Protein ID: WP_015219464.1
• Coordinates: 1956869..1957126 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYAN10605_RS08120	1952515..1953090	-	576	WP_015219459.1	NAD(P)H-quinone oxidoreductase subunit I	-
CYAN10605_RS08125	1953580..1954743	+	1164	WP_015219460.1	ferrochelatase	-
CYAN10605_RS08130	1954829..1955233	+	405	WP_015219461.1	Rieske (2Fe-2S) protein	-
CYAN10605_RS08135	1955237..1955638	-	402	WP_015219462.1	hypothetical protein	-
CYAN10605_RS08140	1955753..1956520	+	768	WP_150108939.1	hypothetical protein	-
CYAN10605_RS08145	1956869..1957126	+	258	WP_015219464.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CYAN10605_RS08150	1957132..1957386	+	255	WP_015219465.1	Txe/YoeB family addiction module toxin	Toxin
CYAN10605_RS08155	1957436..1958023	+	588	WP_015219466.1	septum formation inhibitor Maf	-
CYAN10605_RS08160	1958048..1958266	+	219	WP_015219467.1	hypothetical protein	-
CYAN10605_RS08165	1958556..1959650	+	1095	WP_015219468.1	hydrogenase formation protein HypD	-
CYAN10605_RS08170	1960094..1960807	-	714	WP_015219469.1	cytochrome b/b6 domain-containing protein	-
CYAN10605_RS08175	1960869..1961636	-	768	WP_015219470.1	NAD-dependent epimerase/dehydratase family protein	-
CYAN10605_RS08180	1961716..1962216	-	501	WP_015219471.1	YchJ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10353.94 Da
• Isoelectric Point: 8.8561

>T28604 WP_015219465.1 NC_019776:1957132-1957386 [Cyanobacterium aponinum PCC 10605]
MKISFLEDGWHDYLYWQSQDKKILKRINQIIKDIKRNPFDGIGKPEPLKFDFSGLWSRRINQEHRLIYQVLDDEVIIIQC
RYHY

Nucleotide

• Length: 255 bp

>T28604 NC_019776:1957132-1957386 [Cyanobacterium aponinum PCC 10605]
ATGAAAATTTCCTTTTTAGAAGACGGTTGGCATGATTATTTATATTGGCAAAGTCAGGATAAAAAAATCTTAAAAAGAAT
TAATCAAATCATTAAAGATATAAAAAGAAATCCATTTGATGGTATTGGCAAACCTGAGCCGTTAAAGTTTGATTTTAGCG
GATTATGGTCAAGACGTATTAATCAAGAGCATCGCTTAATTTATCAAGTCTTAGACGATGAGGTTATTATTATTCAATGT
CGTTATCATTATTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9916.35 Da
• Isoelectric Point: 5.6234

>AT28604 WP_015219464.1 NC_019776:1956869-1957126 [Cyanobacterium aponinum PCC 10605]
MDVITYTQARKNFTHVMNEVCENHTPIIITRQSAKPVVMMSLEDYSAIEETLYLLRSPKNAQRLYKALGELKQGKYESHE
LIEEE

Nucleotide

• Length: 258 bp

>AT28604 NC_019776:1956869-1957126 [Cyanobacterium aponinum PCC 10605]
ATGGATGTAATTACTTATACTCAGGCTCGAAAAAACTTTACCCATGTAATGAATGAAGTTTGCGAAAATCATACTCCGAT
TATTATTACTCGTCAATCTGCAAAGCCTGTGGTAATGATGTCCCTTGAGGATTATAGCGCGATCGAAGAGACTTTATATT
TATTACGGAGTCCAAAAAATGCTCAGCGACTTTATAAAGCATTAGGAGAATTAAAACAAGGAAAATACGAAAGTCATGAA
TTAATCGAAGAAGAATAG

Structures

Toxin

• AlphaFold DB: K9Z5T7

Antitoxin

• AlphaFold DB: K9Z4T8