Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1969873..1970649 Replicon chromosome
Accession NZ_LR027874
Organism Staphylococcus aureus strain BPH2056 isolate BPH2056

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag E0E13_RS10025 Protein ID WP_000031108.1
Coordinates 1969873..1970025 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag E0E13_RS10030 Protein ID WP_001251224.1
Coordinates 1970050..1970649 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E13_RS10000 1965836..1966657 + 822 WP_000669375.1 RluA family pseudouridine synthase -
E0E13_RS10005 1967120..1968505 - 1386 WP_000116224.1 class II fumarate hydratase -
E0E13_RS10010 1968701..1969096 - 396 WP_000901021.1 hypothetical protein -
E0E13_RS10025 1969873..1970025 - 153 WP_000031108.1 hypothetical protein Toxin
E0E13_RS10030 1970050..1970649 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
E0E13_RS10035 1970808..1971278 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E0E13_RS10040 1971283..1972410 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
E0E13_RS10045 1972561..1973283 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
E0E13_RS10050 1973276..1974733 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T286038 WP_000031108.1 NZ_LR027874:c1970025-1969873 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT286038 WP_001251224.1 NZ_LR027874:c1970649-1970050 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References