Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2223061..2223590 Replicon chromosome
Accession NZ_LR027873
Organism Staphylococcus aureus strain BPH2070 isolate BPH2070

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E0E08_RS11625 Protein ID WP_000621175.1
Coordinates 2223061..2223423 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E0E08_RS11630 Protein ID WP_000948331.1
Coordinates 2223420..2223590 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E08_RS11600 2220040..2220810 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
E0E08_RS11605 2220785..2221264 - 480 WP_001190829.1 anti-sigma B factor RsbW -
E0E08_RS11610 2221266..2221592 - 327 WP_130825107.1 anti-sigma factor antagonist -
E0E08_RS11615 2221711..2222712 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E0E08_RS11625 2223061..2223423 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E0E08_RS11630 2223420..2223590 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E0E08_RS11635 2223675..2224823 - 1149 WP_001281145.1 alanine racemase -
E0E08_RS11640 2224889..2225248 - 360 WP_000581200.1 holo-ACP synthase -
E0E08_RS11645 2225252..2225743 - 492 WP_001205910.1 PH domain-containing protein -
E0E08_RS11650 2225730..2227313 - 1584 WP_001294626.1 PH domain-containing protein -
E0E08_RS11655 2227306..2227785 - 480 WP_001287088.1 hypothetical protein -
E0E08_RS11660 2227993..2228553 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286027 WP_000621175.1 NZ_LR027873:c2223423-2223061 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286027 WP_000948331.1 NZ_LR027873:c2223590-2223420 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References