Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 860692..861224 Replicon chromosome
Accession NZ_LR027870
Organism Staphylococcus aureus strain BPH2019 isolate BPH2019

Toxin (Protein)


Gene name TscT Uniprot ID Q93CD4
Locus tag E0E15_RS04335 Protein ID WP_001103942.1
Coordinates 860904..861224 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag E0E15_RS04330 Protein ID WP_116100508.1
Coordinates 860692..860901 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E15_RS04295 857022..857486 + 465 WP_001085185.1 SsrA-binding protein SmpB -
E0E15_RS04305 858049..859155 - 1107 WP_106699245.1 site-specific integrase -
E0E15_RS04310 859145..859948 - 804 WP_000358990.1 helix-turn-helix domain-containing protein -
E0E15_RS04315 860084..860287 + 204 WP_001045296.1 transcriptional regulator -
E0E15_RS04320 860323..860541 + 219 WP_000163544.1 helix-turn-helix domain-containing protein -
E0E15_RS04325 860553..860699 + 147 WP_000784885.1 hypothetical protein -
E0E15_RS04330 860692..860901 + 210 WP_116100508.1 pathogenicity island protein Antitoxin
E0E15_RS04335 860904..861224 + 321 WP_001103942.1 DUF1474 family protein Toxin
E0E15_RS04340 861288..862157 + 870 WP_053040303.1 primase alpha helix C-terminal domain-containing protein -
E0E15_RS04345 862174..863643 + 1470 WP_053040304.1 virulence-associated E family protein -
E0E15_RS04350 863922..864284 + 363 WP_001039165.1 hypothetical protein -
E0E15_RS04355 864286..864549 + 264 WP_001804819.1 hypothetical protein -
E0E15_RS04360 864551..865192 + 642 WP_116100509.1 pathogenicity island protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12694.22 Da        Isoelectric Point: 4.7419

>T286008 WP_001103942.1 NZ_LR027870:860904-861224 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Download         Length: 321 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8166.22 Da        Isoelectric Point: 4.4665

>AT286008 WP_116100508.1 NZ_LR027870:860692-860901 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLGKGE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q93CD4

Antitoxin

Source ID Structure

References