Detailed information of TA system TA028600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazE-MazF
• Location: 1437468..1438061
• Replicon: chromosome
• Accession: NC_019776
• Organism: Cyanobacterium aponinum PCC 10605

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: K9Z3J8
• Locus tag: CYAN10605_RS05975
• Protein ID: WP_015219041.1
• Coordinates: 1437468..1437743 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: K9Z4K0
• Locus tag: CYAN10605_RS05980
• Protein ID: WP_015219042.1
• Coordinates: 1437744..1438061 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYAN10605_RS18120	1432749..1433123	+	375	Protein_1172	HEPN domain-containing protein	-
CYAN10605_RS05955	1433161..1434681	+	1521	WP_015219037.1	glycosyltransferase family 1 protein	-
CYAN10605_RS05960	1434689..1435390	+	702	WP_015219038.1	WbqC family protein	-
CYAN10605_RS05965	1435387..1436373	+	987	WP_015219039.1	hypothetical protein	-
CYAN10605_RS05970	1436363..1437352	+	990	WP_015219040.1	sulfotransferase	-
CYAN10605_RS05975	1437468..1437743	+	276	WP_015219041.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Toxin
CYAN10605_RS05980	1437744..1438061	+	318	WP_015219042.1	type II toxin-antitoxin system PemK/MazF family toxin	Antitoxin
CYAN10605_RS05985	1438152..1438481	+	330	WP_015219043.1	XisI protein	-
CYAN10605_RS05990	1438614..1438898	+	285	WP_015219044.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
CYAN10605_RS05995	1438891..1439211	+	321	WP_015219045.1	Txe/YoeB family addiction module toxin	-
CYAN10605_RS17780	1439472..1441850	+	2379	WP_015219046.1	glycosyltransferase	-
CYAN10605_RS06005	1441843..1442223	-	381	WP_015219047.1	HEPN domain-containing protein	-
CYAN10605_RS06010	1442220..1442558	-	339	WP_015219048.1	nucleotidyltransferase domain-containing protein	-
CYAN10605_RS06015	1442650..1442925	-	276	WP_015219049.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• SpoVT-AbrB domain (11-48)

Antitoxin

• mRNA interferase PemK-like (1-102)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10633.90 Da
• Isoelectric Point: 4.2290

>T28600 WP_015219041.1 NC_019776:1437468-1437743 [Cyanobacterium aponinum PCC 10605]
MIENTIHTRLVKIGNSQGVRLPKTLLEIAKIKDQIDLSIEDGTIIIRASEENKVRLNWAKSFQEMASENDDQLLDSDTQT
LSYWDEQEWEW

Nucleotide

• Length: 276 bp

>T28600 NC_019776:1437468-1437743 [Cyanobacterium aponinum PCC 10605]
ATGATAGAAAATACTATTCATACTCGTTTAGTGAAAATTGGTAATTCTCAAGGGGTTAGACTACCCAAAACTCTGCTGGA
AATTGCCAAAATCAAAGATCAAATTGATTTATCCATTGAAGACGGCACAATAATAATTCGTGCTTCAGAAGAAAACAAAG
TAAGGTTAAATTGGGCAAAATCCTTTCAAGAAATGGCTTCTGAAAATGATGATCAACTATTGGATAGCGACACTCAGACG
CTATCCTATTGGGATGAACAAGAATGGGAGTGGTAG

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11986.14 Da
• Isoelectric Point: 8.4798

>AT28600 WP_015219042.1 NC_019776:1437744-1438061 [Cyanobacterium aponinum PCC 10605]
MKRFDIYLINLDPTLGSEIQKTRPCVIISPDEMNDYIKTVIVAPMTSKGKLYPTRIRCNFQEKEGLIVLDQIRTVDKIRL
VKKLGTLDSSIQDEVLSKLGEMFAP

Nucleotide

• Length: 318 bp

>AT28600 NC_019776:1437744-1438061 [Cyanobacterium aponinum PCC 10605]
ATGAAGCGATTTGATATTTACTTAATCAATCTTGATCCTACTCTTGGCAGTGAAATTCAGAAAACTCGTCCTTGTGTGAT
TATTTCCCCTGATGAAATGAATGATTATATTAAAACAGTTATTGTTGCACCTATGACCAGTAAAGGTAAACTTTACCCGA
CTCGGATTAGGTGTAACTTTCAAGAAAAAGAAGGATTAATTGTTTTAGATCAAATTAGAACTGTTGATAAAATTCGTTTA
GTCAAAAAACTTGGTACTCTTGATAGTTCTATTCAAGATGAAGTTTTATCTAAGTTAGGGGAAATGTTTGCTCCGTAA

Structures

Toxin

• AlphaFold DB: K9Z3J8

Antitoxin

• AlphaFold DB: K9Z4K0