Detailed information of TA system TA285992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 873370..873902
• Replicon: chromosome
• Accession: NZ_LR027869
• Organism: Staphylococcus aureus isolate BPH2869

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: E0E09_RS04430
• Protein ID: WP_001103942.1
• Coordinates: 873582..873902 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: E0E09_RS04425
• Protein ID: WP_116100508.1
• Coordinates: 873370..873579 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E09_RS04390	869700..870164	+	465	WP_001085185.1	SsrA-binding protein SmpB	-
E0E09_RS04400	870727..871833	-	1107	WP_106699245.1	site-specific integrase	-
E0E09_RS04405	871823..872626	-	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
E0E09_RS04410	872762..872965	+	204	WP_001045296.1	transcriptional regulator	-
E0E09_RS04415	873001..873219	+	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
E0E09_RS04420	873231..873377	+	147	WP_000784885.1	hypothetical protein	-
E0E09_RS04425	873370..873579	+	210	WP_116100508.1	pathogenicity island protein	Antitoxin
E0E09_RS04430	873582..873902	+	321	WP_001103942.1	DUF1474 family protein	Toxin
E0E09_RS04435	873966..874835	+	870	WP_130826599.1	primase alpha helix C-terminal domain-containing protein	-
E0E09_RS04440	874852..876321	+	1470	WP_053040304.1	virulence-associated E family protein	-
E0E09_RS04445	876600..876962	+	363	WP_001039165.1	hypothetical protein	-
E0E09_RS04450	876964..877227	+	264	WP_001804819.1	hypothetical protein	-
E0E09_RS04455	877229..877870	+	642	WP_116100509.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	ant(9)-Ia / erm(A)	vWbp	867306..918789	51483

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T285992 WP_001103942.1 NZ_LR027869:873582-873902 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8166.22 Da
• Isoelectric Point: 4.4665

>AT285992 WP_116100508.1 NZ_LR027869:873370-873579 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLGKGE

Nucleotide

• Length: 210 bp

Structures

Toxin

• AlphaFold DB: Q93CD4