Detailed information of TA system TA028599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 5697565..5698076
• Replicon: chromosome
• Accession: NC_019771
• Organism: Anabaena cylindrica PCC 7122

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K9ZME3
• Locus tag: ANACY_RS24800
• Protein ID: WP_015216987.1
• Coordinates: 5697816..5698076 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K9ZPU1
• Locus tag: ANACY_RS24795
• Protein ID: WP_015216986.1
• Coordinates: 5697565..5697819 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ANACY_RS24780	5692654..5693733	-	1080	WP_015216982.1	30S ribosomal protein S1	-
ANACY_RS31610	5694044..5694148	-	105	WP_015216983.1	photosystem II reaction center protein T	-
ANACY_RS24785	5694249..5695778	-	1530	WP_015216984.1	photosystem II chlorophyll-binding protein CP47	-
ANACY_RS24790	5696403..5697458	+	1056	WP_015216985.1	hypothetical protein	-
ANACY_RS24795	5697565..5697819	+	255	WP_015216986.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ANACY_RS24800	5697816..5698076	+	261	WP_015216987.1	Txe/YoeB family addiction module toxin	Toxin
ANACY_RS24805	5698101..5698670	+	570	WP_015216988.1	Uma2 family endonuclease	-
ANACY_RS24810	5698785..5700416	+	1632	WP_042466187.1	ABC transporter substrate-binding protein	-
ANACY_RS24815	5700638..5701663	+	1026	WP_015216990.1	ABC transporter permease	-
ANACY_RS24820	5701722..5702237	-	516	WP_015216991.1	hypothetical protein	-
ANACY_RS24825	5702257..5702958	-	702	WP_015216992.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10342.91 Da
• Isoelectric Point: 7.1643

>T28599 WP_015216987.1 NC_019771:5697816-5698076 [Anabaena cylindrica PCC 7122]
MKLTFTESAWEDYLWFQETDKKLLKRINTLIKEILRSPVEGIGKPEQLKANLSGYWSRRINTEHRLVYEVLEDNIIIVAC
RFHYQD

Nucleotide

• Length: 261 bp

>T28599 NC_019771:5697816-5698076 [Anabaena cylindrica PCC 7122]
ATGAAACTCACATTTACAGAATCTGCATGGGAGGATTATTTGTGGTTTCAAGAGACTGATAAGAAACTCTTGAAAAGAAT
CAATACTCTAATTAAAGAAATTCTGCGGAGTCCTGTTGAGGGCATTGGTAAACCAGAACAATTGAAAGCTAATTTATCAG
GTTATTGGTCAAGGCGCATCAACACCGAACACCGATTAGTATATGAAGTGTTAGAAGACAACATAATTATTGTAGCTTGT
CGGTTTCATTATCAAGATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9285.52 Da
• Isoelectric Point: 4.0334

>AT28599 WP_015216986.1 NC_019771:5697565-5697819 [Anabaena cylindrica PCC 7122]
MDAMTTQQASNDLDGLIDRVIADVEPTIICNNKGNKAILISLDEFSSWQETLYLLSNPVNAKHLLTSIQLAKAGEVVERD
LIEE

Nucleotide

• Length: 255 bp

>AT28599 NC_019771:5697565-5697819 [Anabaena cylindrica PCC 7122]
ATGGATGCAATGACTACTCAGCAAGCAAGTAATGACTTAGATGGTTTGATAGATCGGGTTATTGCAGATGTAGAACCAAC
AATTATTTGTAATAACAAAGGCAATAAGGCTATTTTAATTTCTCTAGACGAATTTTCATCATGGCAAGAAACATTGTATT
TACTGTCAAATCCTGTTAATGCCAAGCATCTTCTTACCTCAATTCAATTAGCAAAAGCAGGTGAAGTTGTTGAGAGAGAT
TTAATTGAAGAATGA

Structures

Toxin

• AlphaFold DB: K9ZME3

Antitoxin

• AlphaFold DB: K9ZPU1