Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1750281..1751497 Replicon chromosome
Accession NZ_LR027557
Organism Pseudomonas synxantha strain 10586

Toxin (Protein)


Gene name vapC Uniprot ID I4L4R8
Locus tag KR485_RS07440 Protein ID WP_005789605.1
Coordinates 1750925..1751497 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KR485_RS07435 Protein ID WP_122733824.1
Coordinates 1750281..1750838 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KR485_RS07420 1745807..1746547 + 741 WP_078821820.1 molecular chaperone -
KR485_RS07425 1746633..1749143 + 2511 WP_078821821.1 fimbria/pilus outer membrane usher protein -
KR485_RS07430 1749203..1750039 + 837 WP_216091802.1 HAD family acid phosphatase -
KR485_RS07435 1750281..1750838 + 558 WP_122733824.1 helix-turn-helix transcriptional regulator Antitoxin
KR485_RS07440 1750925..1751497 + 573 WP_005789605.1 HD domain-containing protein Toxin
KR485_RS07445 1751507..1751929 - 423 WP_005789607.1 RidA family protein -
KR485_RS07450 1751941..1753524 - 1584 WP_216091803.1 FAD-dependent oxidoreductase -
KR485_RS07455 1753535..1754458 - 924 WP_216091804.1 ABC transporter substrate-binding protein -
KR485_RS07460 1754477..1755250 - 774 WP_216091805.1 amino acid ABC transporter ATP-binding protein -
KR485_RS07465 1755243..1756214 - 972 WP_078821826.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-46)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21318.42 Da        Isoelectric Point: 5.1232

>T285986 WP_005789605.1 NZ_LR027557:1750925-1751497 [Pseudomonas synxantha]
MDMEKIKGRLDFLREAEKLKDVLRSAHTASGRTESTAEHSWRLCLMAMVFADQLPGLDLLKILKMCVIHDLGEAIHGDIP
AVSQAAFPNKGEQERLDLLLLAQSLDSPLKAEILTLWDDYENARSPEAKAVKAMDKLETLLQHTQGLNPPDFDYAFNLAY
GKKHTDADPLFEALRALIDRATEQRLHAAE

Download         Length: 573 bp

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20548.56 Da        Isoelectric Point: 8.8351

>AT285986 WP_122733824.1 NZ_LR027557:1750281-1750838 [Pseudomonas synxantha]
MPHSLLKPALPGVALRRWRLLHRIKQSHTAQLFNVTQSTISRWESGVQAMDPAAHQQLEQLLAARLDAAADQALARLVSE
SSQAMHLVCDLTHRLLACSPSRARQFSSPLAELMGQSLWRFATPQIQLIEASLEHTGWRETQAPPALEFTTGSNDSNLVP
IRPSLCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S7MQZ9

Antitoxin

Source ID Structure

References