Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 61657..62218 Replicon plasmid 4
Accession NZ_LR027556
Organism Epibacterium mobile isolate EPIB1

Toxin (Protein)


Gene name relE Uniprot ID A0A1H3GZP2
Locus tag PEPIB2_RS21820 Protein ID WP_065331750.1
Coordinates 61943..62218 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1N7QLX2
Locus tag PEPIB2_RS21815 Protein ID WP_044353023.1
Coordinates 61657..61956 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PEPIB2_RS21795 57461..58822 + 1362 WP_027246198.1 ISKra4 family transposase -
PEPIB2_RS21800 58845..60230 + 1386 Protein_58 chromosome partitioning protein ParB -
PEPIB2_RS21805 60305..60898 + 594 WP_065331748.1 regulator -
PEPIB2_RS21810 60898..61554 + 657 WP_065331962.1 hypothetical protein -
PEPIB2_RS21815 61657..61956 + 300 WP_044353023.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PEPIB2_RS21820 61943..62218 + 276 WP_065331750.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
PEPIB2_RS21825 62325..66587 + 4263 WP_065331751.1 strawberry notch family protein -
PEPIB2_RS21830 66710..67096 + 387 WP_065331752.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..187172 187172
- flank IS/Tn - - 57461..58822 1361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-54)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10404.97 Da        Isoelectric Point: 4.5837

>T285984 WP_065331750.1 NZ_LR027556:61943-62218 [Epibacterium mobile]
MPNLEWKATAIADLLAIIDYISDDNPDAAQVLKDEIEHKTSLLPERPQMYRAGRVDGTREMVVRPNYIVVYAESLEMVTI
LRVLHAAQQWP

Download         Length: 276 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10462.91 Da        Isoelectric Point: 5.6448

>AT285984 WP_044353023.1 NZ_LR027556:61657-61956 [Epibacterium mobile]
MPAQTSMLHVRVDDQLKAQASDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALDDPRPTTPH
AKAMQDAQALIDGKRLAKS

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H3GZP2

Antitoxin

Source ID Structure
AlphaFold DB A0A1N7QLX2

References