Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3825731..3826416 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag DKC2_RS18710 Protein ID WP_003417998.1
Coordinates 3826006..3826416 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DKC2_RS18705 Protein ID WP_003912220.1
Coordinates 3825731..3826009 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS18685 3821720..3823321 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
DKC2_RS18690 3823338..3824042 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
DKC2_RS18695 3824160..3824726 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
DKC2_RS18700 3824788..3825675 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
DKC2_RS18705 3825731..3826009 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DKC2_RS18710 3826006..3826416 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
DKC2_RS18715 3826449..3828185 - 1737 WP_003418002.1 cholesterol oxidase -
DKC2_RS18720 3828241..3829368 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
DKC2_RS18725 3829388..3830977 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T285981 WP_003417998.1 NZ_LR027516:3826006-3826416 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT285981 WP_003912220.1 NZ_LR027516:3825731-3826009 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References