Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3771464..3771993 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag DKC2_RS18445 Protein ID WP_003417760.1
Coordinates 3771736..3771993 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag DKC2_RS18440 Protein ID WP_003417757.1
Coordinates 3771464..3771739 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS21960 3768262..3769699 - 1438 Protein_3468 FAD-binding oxidoreductase -
DKC2_RS18425 3769802..3770191 + 390 WP_003417745.1 DUF732 domain-containing protein -
DKC2_RS18430 3770205..3770498 - 294 WP_003417749.1 DUF3017 domain-containing protein -
DKC2_RS18435 3770495..3771340 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
DKC2_RS18440 3771464..3771739 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
DKC2_RS18445 3771736..3771993 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
DKC2_RS18450 3772035..3773225 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
DKC2_RS18455 3773342..3773710 + 369 WP_003417765.1 FHA domain-containing protein -
DKC2_RS18460 3773707..3774258 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
DKC2_RS18465 3774265..3774846 - 582 WP_003417769.1 ATP/GTP-binding protein -
DKC2_RS18470 3774827..3775195 - 369 WP_003417772.1 DUF742 domain-containing protein -
DKC2_RS18475 3775173..3775565 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T285979 WP_003417760.1 NZ_LR027516:3771736-3771993 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT285979 WP_003417757.1 NZ_LR027516:3771464-3771739 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References