Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3076969..3077648 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WF90
Locus tag DKC2_RS15120 Protein ID WP_003414059.1
Coordinates 3076969..3077385 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag DKC2_RS15125 Protein ID WP_003414061.1
Coordinates 3077382..3077648 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS15100 3073021..3073923 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
DKC2_RS15105 3073992..3074744 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
DKC2_RS15110 3074988..3075263 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
DKC2_RS15115 3075260..3076882 - 1623 WP_003906897.1 type I restriction-modification system subunit M -
DKC2_RS15120 3076969..3077385 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 Toxin
DKC2_RS15125 3077382..3077648 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DKC2_RS15130 3077674..3078069 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin -
DKC2_RS15135 3078066..3078335 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
DKC2_RS15140 3078345..3079439 - 1095 WP_003414068.1 restriction endonuclease subunit S -
DKC2_RS15145 3079436..3079855 - 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
DKC2_RS15150 3079929..3080408 - 480 WP_003414073.1 dihydrofolate reductase -
DKC2_RS15155 3080479..3081279 - 801 WP_003911953.1 thymidylate synthase -
DKC2_RS15160 3081435..3082172 + 738 WP_031746397.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15773.00 Da        Isoelectric Point: 7.1294

>T285970 WP_003414059.1 NZ_LR027516:c3077385-3076969 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT285970 WP_003414061.1 NZ_LR027516:c3077648-3077382 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5SV2

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References