Detailed information of TA system TA028597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 4406002..4406485
• Replicon: chromosome
• Accession: NC_019771
• Organism: Anabaena cylindrica PCC 7122

Toxin (Protein)

• Gene name: -
• Uniprot ID: K9ZL35
• Locus tag: ANACY_RS19125
• Protein ID: WP_015215863.1
• Coordinates: 4406002..4406262 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: K9ZJ44
• Locus tag: ANACY_RS19130
• Protein ID: WP_015215864.1
• Coordinates: 4406252..4406485 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ANACY_RS19110	4402042..4404123	-	2082	WP_015215860.1	dynamin family protein	-
ANACY_RS19115	4404136..4404441	-	306	WP_015215861.1	hypothetical protein	-
ANACY_RS19120	4404766..4405740	+	975	WP_015215862.1	cysteine synthase A	-
ANACY_RS19125	4406002..4406262	+	261	WP_015215863.1	BrnT family toxin	Toxin
ANACY_RS19130	4406252..4406485	+	234	WP_015215864.1	CopG family transcriptional regulator	Antitoxin
ANACY_RS19135	4406531..4406845	+	315	WP_015215865.1	(2Fe-2S) ferredoxin domain-containing protein	-
ANACY_RS19140	4406900..4407667	+	768	WP_015215866.1	hypothetical protein	-
ANACY_RS19145	4407770..4408771	-	1002	WP_015215867.1	folate-binding protein YgfZ	-
ANACY_RS19150	4409292..4410125	+	834	WP_042466086.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-80)

Antitoxin

• CopG antitoxin (2-69)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10171.53 Da
• Isoelectric Point: 8.5489

>T28597 WP_015215863.1 NC_019771:4406002-4406262 [Anabaena cylindrica PCC 7122]
MEFEFDSNKSAINKTKHGIDFIEAQKLWTDVNRIEISARTEDEARFLVIAKIADKHWSGVITYRNDKIRIISVRRSRNEE
VKIYES

Nucleotide

• Length: 261 bp

>T28597 NC_019771:4406002-4406262 [Anabaena cylindrica PCC 7122]
ATGGAGTTTGAATTTGACTCTAACAAAAGTGCAATTAATAAAACCAAGCATGGTATTGATTTTATTGAAGCGCAAAAACT
TTGGACAGATGTAAATCGTATAGAAATTTCAGCACGCACAGAAGATGAGGCTCGTTTTTTAGTCATCGCCAAGATTGCCG
ATAAACATTGGTCAGGAGTCATTACTTATCGTAATGATAAAATAAGAATTATTTCAGTTCGTCGTTCTCGTAATGAAGAG
GTAAAAATTTATGAAAGCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9000.21 Da
• Isoelectric Point: 4.5517

>AT28597 WP_015215864.1 NC_019771:4406252-4406485 [Anabaena cylindrica PCC 7122]
MKAEEFDAKFDDDEDITDFLDLSKARRPGYEQKRINIDFPIWMIEALEHEAKRLGVTSDSIIKLWLAERLDKKVTSG

Nucleotide

• Length: 234 bp

>AT28597 NC_019771:4406252-4406485 [Anabaena cylindrica PCC 7122]
ATGAAAGCTGAAGAGTTTGATGCAAAATTTGACGACGATGAAGACATTACTGATTTCTTGGATTTATCTAAAGCACGTCG
TCCAGGTTATGAACAAAAACGAATTAATATTGATTTCCCCATTTGGATGATTGAAGCTTTAGAACATGAAGCTAAACGTT
TGGGTGTTACTTCTGATTCTATTATTAAATTGTGGCTTGCTGAACGTCTTGATAAAAAAGTTACTAGTGGATAA

Structures

Toxin

• AlphaFold DB: K9ZL35

Antitoxin

• AlphaFold DB: K9ZJ44