Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2877734..2878371 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag DKC2_RS13990 Protein ID WP_003413180.1
Coordinates 2877734..2878129 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag DKC2_RS13995 Protein ID WP_003413183.1
Coordinates 2878126..2878371 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS13945 2873137..2874348 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
DKC2_RS13955 2874475..2875134 + 660 WP_003900846.1 LppA family lipoprotein -
DKC2_RS13960 2875131..2875793 + 663 WP_003900848.1 hypothetical protein -
DKC2_RS13965 2875790..2876068 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
DKC2_RS13970 2876161..2876574 + 414 WP_003413164.1 PIN domain nuclease -
DKC2_RS13975 2876613..2876870 + 258 WP_031746422.1 ribbon-helix-helix domain-containing protein -
DKC2_RS13980 2876867..2877244 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
DKC2_RS13985 2877260..2877634 - 375 WP_003413177.1 hypothetical protein -
DKC2_RS13990 2877734..2878129 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
DKC2_RS13995 2878126..2878371 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
DKC2_RS14005 2878782..2879201 - 420 WP_003413190.1 A24 family peptidase -
DKC2_RS14010 2879213..2880022 - 810 WP_003413193.1 shikimate dehydrogenase -
DKC2_RS14015 2880019..2881272 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
DKC2_RS14020 2881265..2881777 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T285967 WP_003413180.1 NZ_LR027516:c2878129-2877734 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT285967 WP_003413183.1 NZ_LR027516:c2878371-2878126 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References