Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2374770..2375465 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag DKC2_RS11480 Protein ID WP_003410811.1
Coordinates 2374770..2375204 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag DKC2_RS11485 Protein ID WP_003410814.1
Coordinates 2375211..2375465 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS11470 2370924..2373965 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
DKC2_RS11475 2373958..2374791 + 834 WP_003899172.1 SWIM zinc finger family protein -
DKC2_RS11480 2374770..2375204 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
DKC2_RS11485 2375211..2375465 - 255 WP_003410814.1 antitoxin Antitoxin
DKC2_RS11490 2375481..2375738 - 258 WP_003410816.1 hypothetical protein -
DKC2_RS11500 2376685..2376981 + 297 WP_003410820.1 PE family protein -
DKC2_RS11505 2377037..2377768 + 732 WP_003900467.1 PPE family protein -
DKC2_RS11510 2378308..2379054 - 747 WP_003906749.1 proteasome subunit alpha -
DKC2_RS11515 2379051..2379926 - 876 WP_003411023.1 proteasome subunit beta -
DKC2_RS11520 2379923..2380117 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T285961 WP_003410811.1 NZ_LR027516:c2375204-2374770 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT285961 WP_003410814.1 NZ_LR027516:c2375465-2375211 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References