Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2268729..2269355 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag DKC2_RS10995 Protein ID WP_003410075.1
Coordinates 2268957..2269355 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag DKC2_RS10990 Protein ID WP_003911750.1
Coordinates 2268729..2268956 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS10980 2266768..2267112 - 345 WP_003410065.1 ferredoxin family protein -
DKC2_RS10985 2267301..2268470 - 1170 WP_003899126.1 ATP-binding protein -
DKC2_RS10990 2268729..2268956 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DKC2_RS10995 2268957..2269355 + 399 WP_003410075.1 PIN domain nuclease Toxin
DKC2_RS11000 2269538..2269969 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
DKC2_RS11005 2270070..2270504 + 435 WP_003914358.1 DUF1398 domain-containing protein -
DKC2_RS11020 2270941..2271120 - 180 Protein_2083 hypothetical protein -
DKC2_RS11025 2271181..2271828 + 648 WP_071854215.1 transposase -
DKC2_RS11030 2271782..2272372 + 591 WP_003899131.1 IS110 family transposase -
DKC2_RS11035 2272500..2273756 - 1257 WP_003410095.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T285958 WP_003410075.1 NZ_LR027516:2268957-2269355 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT285958 WP_003911750.1 NZ_LR027516:2268729-2268956 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References