Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2244989..2245575 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag DKC2_RS10895 Protein ID WP_003410010.1
Coordinates 2244989..2245333 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag DKC2_RS10900 Protein ID WP_003410014.1
Coordinates 2245327..2245575 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS10855 2240695..2241294 + 600 WP_003409989.1 L-lysine exporter -
DKC2_RS10860 2241710..2242138 + 429 WP_003409992.1 cellulose-binding protein -
DKC2_RS10865 2242364..2242903 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
DKC2_RS10875 2243423..2243983 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
DKC2_RS10880 2243980..2244321 - 342 WP_003410003.1 DUF2384 domain-containing protein -
DKC2_RS10885 2244407..2244664 + 258 WP_003410006.1 hypothetical protein -
DKC2_RS10890 2244565..2244900 - 336 WP_003410009.1 dehydrogenase -
DKC2_RS10895 2244989..2245333 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
DKC2_RS10900 2245327..2245575 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
DKC2_RS10905 2245675..2247990 - 2316 WP_003899120.1 cation transporter ATPase CptG -
DKC2_RS10910 2247987..2248259 - 273 WP_003410017.1 DUF1490 family protein -
DKC2_RS10915 2248312..2248668 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
DKC2_RS10920 2248825..2249592 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T285957 WP_003410010.1 NZ_LR027516:c2245333-2244989 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT285957 WP_003410014.1 NZ_LR027516:c2245575-2245327 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References