Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2205327..2206030 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag DKC2_RS10605 Protein ID WP_003409778.1
Coordinates 2205327..2205656 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag DKC2_RS10610 Protein ID WP_003409780.1
Coordinates 2205653..2206030 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS10585 2201710..2202780 + 1071 WP_003899091.1 epoxide hydrolase EphB -
DKC2_RS10590 2202777..2203292 + 516 WP_003409718.1 flavin reductase family protein -
DKC2_RS10595 2203289..2204350 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
DKC2_RS10600 2204347..2205117 + 771 WP_003409775.1 SDR family oxidoreductase -
DKC2_RS10605 2205327..2205656 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DKC2_RS10610 2205653..2206030 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
DKC2_RS10615 2206027..2206617 - 591 WP_003409784.1 SEC-C domain-containing protein -
DKC2_RS10620 2206672..2208036 + 1365 WP_003899094.1 HNH endonuclease -
DKC2_RS10625 2208191..2208643 - 453 WP_003899095.1 lipoprotein -
DKC2_RS10630 2208707..2209108 + 402 WP_003409869.1 hypothetical protein -
DKC2_RS10635 2209101..2209283 - 183 WP_003409870.1 hypothetical protein -
DKC2_RS10640 2209397..2209747 - 351 WP_003899096.1 hypothetical protein -
DKC2_RS10645 2209758..2210660 - 903 WP_003899097.1 hypothetical protein -
DKC2_RS10650 2210681..2210872 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T285952 WP_003409778.1 NZ_LR027516:c2205656-2205327 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT285952 WP_003409780.1 NZ_LR027516:c2206030-2205653 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References