Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1974446..1974906 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag DKC2_RS09520 Protein ID WP_003898996.1
Coordinates 1974658..1974906 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag DKC2_RS09515 Protein ID WP_003408528.1
Coordinates 1974446..1974658 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS09500 1970924..1972111 - 1188 WP_003898992.1 nitrate transporter NarK -
DKC2_RS09505 1972398..1972682 + 285 WP_003408522.1 DUF1876 domain-containing protein -
DKC2_RS09510 1972696..1974378 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
DKC2_RS09515 1974446..1974658 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DKC2_RS09520 1974658..1974906 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
DKC2_RS09525 1974914..1975651 + 738 WP_003898997.1 hypothetical protein -
DKC2_RS09530 1975745..1977445 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
DKC2_RS09535 1977730..1978131 - 402 WP_003408538.1 hypothetical protein -
DKC2_RS09540 1978121..1978732 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T285951 WP_003898996.1 NZ_LR027516:1974658-1974906 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT285951 WP_003408528.1 NZ_LR027516:1974446-1974658 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References