Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1953770..1954383 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag DKC2_RS09405 Protein ID WP_003408465.1
Coordinates 1953770..1954159 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag DKC2_RS09410 Protein ID WP_003408469.1
Coordinates 1954156..1954383 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS09375 1949399..1950313 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
DKC2_RS09380 1950316..1951146 + 831 WP_003916363.1 cyclase family protein -
DKC2_RS09385 1951146..1951496 + 351 WP_003898986.1 cupin domain-containing protein -
DKC2_RS09390 1951549..1952367 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
DKC2_RS09395 1952381..1953160 + 780 WP_003408460.1 IclR family transcriptional regulator -
DKC2_RS09405 1953770..1954159 - 390 WP_003408465.1 PIN domain-containing protein Toxin
DKC2_RS09410 1954156..1954383 - 228 WP_003408469.1 antitoxin Antitoxin
DKC2_RS09415 1954601..1956085 + 1485 WP_003408473.1 carboxylase -
DKC2_RS09420 1956082..1957329 + 1248 WP_003408476.1 serine hydrolase -
DKC2_RS09425 1957372..1957791 - 420 WP_003408483.1 hypothetical protein -
DKC2_RS09430 1957781..1958491 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T285950 WP_003408465.1 NZ_LR027516:c1954159-1953770 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT285950 WP_003408469.1 NZ_LR027516:c1954383-1954156 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References