Detailed information of TA system TA028595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 2497374..2498020
• Replicon: chromosome
• Accession: NC_019771
• Organism: Anabaena cylindrica PCC 7122

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K9ZEP5
• Locus tag: ANACY_RS10925
• Protein ID: WP_015214303.1
• Coordinates: 2497616..2498020 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K9ZH37
• Locus tag: ANACY_RS10920
• Protein ID: WP_015214302.1
• Coordinates: 2497374..2497619 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ANACY_RS10890	2492872..2493387	-	516	WP_015214299.1	peptidylprolyl isomerase	-
ANACY_RS10895	2493543..2494121	-	579	WP_015214300.1	hypothetical protein	-
ANACY_RS10900	2494454..2495030	+	577	Protein_2164	ISAs1 family transposase	-
ANACY_RS10905	2495051..2496583	-	1533	WP_171815787.1	slipin family protein	-
ANACY_RS10920	2497374..2497619	+	246	WP_015214302.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ANACY_RS10925	2497616..2498020	+	405	WP_015214303.1	type II toxin-antitoxin system VapC family toxin	Toxin
ANACY_RS10930	2498084..2498671	-	588	Protein_2168	hypothetical protein	-
ANACY_RS10935	2498646..2499248	-	603	WP_015214305.1	ATP-binding protein	-
ANACY_RS10940	2499261..2499485	-	225	WP_015214306.1	hypothetical protein	-
ANACY_RS10945	2499485..2499904	-	420	WP_015214307.1	hypothetical protein	-
ANACY_RS10950	2499897..2500112	-	216	WP_042465955.1	hypothetical protein	-
ANACY_RS10955	2500236..2501465	-	1230	WP_015214309.1	DUF4935 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (4-129)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-42)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15130.59 Da
• Isoelectric Point: 5.1754

>T28595 WP_015214303.1 NC_019771:2497616-2498020 [Anabaena cylindrica PCC 7122]
VKLLLDTQCFLWWFAEPERLHEEAIAHIADESNELWLSVASVWEMGIKVAIGKLPLPEPLDSYISSRMMKLGAKSLEITA
SHALRTVALPLHHRDPFDRMLIAQAQMESMTLVTADSMLKEYQDTAILWAGNKG

Nucleotide

• Length: 405 bp

>T28595 NC_019771:2497616-2498020 [Anabaena cylindrica PCC 7122]
GTGAAACTTTTACTGGATACACAGTGTTTTTTATGGTGGTTTGCTGAACCTGAGCGTTTGCATGAAGAAGCGATCGCACA
TATTGCTGATGAAAGCAATGAACTATGGCTTTCTGTAGCTAGTGTGTGGGAAATGGGGATAAAAGTTGCAATTGGTAAGT
TACCATTACCAGAACCACTGGATAGTTACATTTCTAGCCGCATGATGAAATTGGGGGCGAAATCTTTGGAAATTACAGCT
TCTCATGCACTCAGAACGGTGGCTTTACCGTTGCATCATCGAGATCCTTTCGACAGAATGCTCATTGCACAAGCACAGAT
GGAAAGTATGACGCTTGTGACTGCGGATTCAATGCTTAAAGAGTATCAAGATACTGCTATTCTTTGGGCTGGGAATAAAG
GTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9037.18 Da
• Isoelectric Point: 5.0873

>AT28595 WP_015214302.1 NC_019771:2497374-2497619 [Anabaena cylindrica PCC 7122]
METVNIHQAKTNLSRLLSRVEHGEEIIISNRGVPVAKLVPFSVSSHRRDSLGQDRGKFVIPEDFNAPLPEDILAAFEANE
E

Nucleotide

• Length: 246 bp

>AT28595 NC_019771:2497374-2497619 [Anabaena cylindrica PCC 7122]
ATGGAAACTGTAAATATCCATCAAGCTAAAACGAATCTCTCACGTCTATTATCCCGTGTAGAACATGGGGAAGAGATTAT
TATTTCTAACCGGGGTGTTCCCGTCGCTAAGTTAGTTCCGTTTAGTGTTTCGTCTCACCGCAGAGATAGTTTAGGACAAG
ATCGAGGAAAATTTGTAATTCCAGAAGACTTTAATGCACCTTTACCAGAGGACATTTTGGCAGCGTTTGAGGCTAATGAG
GAGTGA

Structures

Toxin

• AlphaFold DB: K9ZEP5

Antitoxin

• AlphaFold DB: K9ZH37