Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1779388..1780001 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag DKC2_RS08640 Protein ID WP_003407786.1
Coordinates 1779597..1780001 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag DKC2_RS08635 Protein ID WP_009935474.1
Coordinates 1779388..1779591 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS08605 1774793..1775173 + 381 WP_003407768.1 fumarate reductase subunit C -
DKC2_RS08610 1775170..1775547 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
DKC2_RS08615 1775615..1776223 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
DKC2_RS08620 1776407..1777555 + 1149 Protein_1627 MMPL family transporter -
DKC2_RS08625 1777565..1778011 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
DKC2_RS08630 1778046..1779335 + 1290 WP_003407781.1 threonine ammonia-lyase -
DKC2_RS08635 1779388..1779591 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DKC2_RS08640 1779597..1780001 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
DKC2_RS08645 1780018..1781760 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
DKC2_RS08650 1781753..1784050 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T285949 WP_003407786.1 NZ_LR027516:1779597-1780001 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT285949 WP_009935474.1 NZ_LR027516:1779388-1779591 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References