Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1588486..1589141 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag DKC2_RS07750 Protein ID WP_003898861.1
Coordinates 1588486..1588887 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag DKC2_RS07755 Protein ID WP_003407272.1
Coordinates 1588884..1589141 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS07735 1583958..1585343 - 1386 WP_003911514.1 cytochrome P450 -
DKC2_RS07740 1585421..1586455 + 1035 WP_003407264.1 AraC family transcriptional regulator -
DKC2_RS07745 1586501..1588231 - 1731 WP_010886114.1 PE family protein -
DKC2_RS07750 1588486..1588887 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
DKC2_RS07755 1588884..1589141 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
DKC2_RS07760 1589224..1590183 - 960 WP_003407276.1 alpha/beta hydrolase -
DKC2_RS07765 1590208..1591170 - 963 WP_003407279.1 alpha/beta hydrolase -
DKC2_RS07770 1591169..1591906 + 738 WP_031647000.1 lysoplasmalogenase -
DKC2_RS07775 1591987..1593954 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T285947 WP_003898861.1 NZ_LR027516:c1588887-1588486 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT285947 WP_003407272.1 NZ_LR027516:c1589141-1588884 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References