Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1554122..1555172 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag DKC2_RS07595 Protein ID WP_003407164.1
Coordinates 1554122..1554943 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag DKC2_RS07600 Protein ID WP_003407167.1
Coordinates 1554936..1555172 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS07575 1549680..1550342 - 663 WP_003407152.1 membrane protein -
DKC2_RS07580 1550339..1551124 - 786 WP_003407157.1 membrane protein -
DKC2_RS07585 1551415..1553376 - 1962 WP_003407159.1 sigma-F factor regulator -
DKC2_RS07590 1553515..1553901 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
DKC2_RS07595 1554122..1554943 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
DKC2_RS07600 1554936..1555172 + 237 WP_003407167.1 hypothetical protein Antitoxin
DKC2_RS07605 1555244..1556449 - 1206 WP_003898846.1 serine hydrolase -
DKC2_RS07610 1556752..1557537 + 786 WP_003407180.1 lipoprotein LprF -
DKC2_RS07615 1557733..1559202 + 1470 WP_003900326.1 fatty acid desaturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T285946 WP_003407164.1 NZ_LR027516:1554122-1554943 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT285946 WP_003407167.1 NZ_LR027516:1554936-1555172 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References