285944

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1398344..1399032 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag DKC2_RS06890 Protein ID WP_003406304.1
Coordinates 1398601..1399032 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag DKC2_RS06885 Protein ID WP_003406302.1
Coordinates 1398344..1398604 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS06865 1393921..1394745 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
DKC2_RS06870 1394750..1395931 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
DKC2_RS06875 1396008..1397108 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
DKC2_RS06880 1397279..1398268 + 990 WP_003406301.1 malate dehydrogenase -
DKC2_RS06885 1398344..1398604 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
DKC2_RS06890 1398601..1399032 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
DKC2_RS06895 1399055..1400743 - 1689 WP_003910308.1 PE family protein -
DKC2_RS06905 1400923..1401783 + 861 WP_003900301.1 hypothetical protein -
DKC2_RS06910 1401864..1402694 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
DKC2_RS06915 1402751..1403044 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
DKC2_RS06920 1403041..1403310 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T285944 WP_003406304.1 NZ_LR027516:1398601-1399032 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT285944 WP_003406302.1 NZ_LR027516:1398344-1398604 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References