Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1038249..1039222 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag DKC2_RS05095 Protein ID WP_003404756.1
Coordinates 1038722..1039222 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID O05910
Locus tag DKC2_RS05090 Protein ID WP_003898647.1
Coordinates 1038249..1038725 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS05070 1034096..1035367 - 1272 WP_003404747.1 PPE family protein -
DKC2_RS05075 1035382..1035681 - 300 WP_003404748.1 PE family protein -
DKC2_RS05080 1036125..1037906 + 1782 WP_003404749.1 BCCT family transporter -
DKC2_RS05085 1037903..1038160 + 258 WP_003404750.1 hypothetical protein -
DKC2_RS05090 1038249..1038725 + 477 WP_003898647.1 DUF1778 domain-containing protein Antitoxin
DKC2_RS05095 1038722..1039222 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
DKC2_RS05105 1039535..1040854 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
DKC2_RS05110 1041142..1041723 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
DKC2_RS05115 1041723..1043375 + 1653 WP_003404761.1 IS607 family element transposase accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T285940 WP_003404756.1 NZ_LR027516:1038722-1039222 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17387.98 Da        Isoelectric Point: 11.2467

>AT285940 WP_003898647.1 NZ_LR027516:1038249-1038725 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB A5U0V8

References