Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 767161..767953 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag DKC2_RS03645 Protein ID WP_003403386.1
Coordinates 767516..767953 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DKC2_RS03640 Protein ID WP_138227976.1
Coordinates 767161..767406 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS03610 762181..763686 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
DKC2_RS03615 763767..764777 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
DKC2_RS03620 765165..765548 - 384 WP_003403365.1 ribonuclease VapC6 -
DKC2_RS03625 765643..765798 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
DKC2_RS03630 765874..766590 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
DKC2_RS03635 766866..767174 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
DKC2_RS03640 767161..767406 - 246 WP_138227976.1 ribbon-helix-helix protein, CopG family Antitoxin
DKC2_RS03645 767516..767953 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
DKC2_RS03650 767950..768204 - 255 WP_003911263.1 antitoxin VapB7 -
DKC2_RS03655 768318..770681 + 2364 WP_003898547.1 arylsulfatase AtsD -
DKC2_RS03660 770744..771070 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DKC2_RS03665 770982..771320 + 339 WP_003403405.1 PIN domain-containing protein -
DKC2_RS03670 771317..771490 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T285936 WP_003403386.1 NZ_LR027516:c767953-767516 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9149.96 Da        Isoelectric Point: 4.2065

>AT285936 WP_138227976.1 NZ_LR027516:c767406-767161 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRHHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure

References