Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 728591..729240 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag DKC2_RS03435 Protein ID WP_003403236.1
Coordinates 728845..729240 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag DKC2_RS03430 Protein ID WP_003403235.1
Coordinates 728591..728845 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS21560 723717..724412 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
DKC2_RS21565 724409..724900 + 492 WP_012054156.1 galactose-1-phosphate uridylyltransferase -
DKC2_RS03410 724897..725988 + 1092 WP_003906403.1 galactokinase -
DKC2_RS03420 726383..727447 + 1065 WP_003898532.1 hypothetical protein -
DKC2_RS03425 727551..728498 + 948 WP_003403232.1 DUF732 domain-containing protein -
DKC2_RS03430 728591..728845 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
DKC2_RS03435 728845..729240 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
DKC2_RS03440 729334..730074 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
DKC2_RS03445 730206..730466 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DKC2_RS03450 730463..730870 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
DKC2_RS03455 730942..732093 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
DKC2_RS03460 732186..733913 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T285932 WP_003403236.1 NZ_LR027516:728845-729240 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT285932 WP_003403235.1 NZ_LR027516:728591-728845 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References