Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 722963..723588 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag DKC2_RS03400 Protein ID WP_003403218.1
Coordinates 723187..723588 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag DKC2_RS03395 Protein ID WP_003403213.1
Coordinates 722963..723190 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS03365 718142..718363 - 222 WP_003898525.1 DUF4926 domain-containing protein -
DKC2_RS03370 718505..719110 + 606 WP_003898526.1 hypothetical protein -
DKC2_RS03375 719129..721696 - 2568 WP_003900188.1 SEC-C domain-containing protein -
DKC2_RS03380 721780..722529 + 750 WP_003898528.1 hypothetical protein -
DKC2_RS03385 722526..722768 + 243 WP_003403210.1 hypothetical protein -
DKC2_RS03395 722963..723190 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
DKC2_RS03400 723187..723588 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
DKC2_RS21560 723717..724412 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
DKC2_RS21565 724409..724900 + 492 WP_012054156.1 galactose-1-phosphate uridylyltransferase -
DKC2_RS03410 724897..725988 + 1092 WP_003906403.1 galactokinase -
DKC2_RS03420 726383..727447 + 1065 WP_003898532.1 hypothetical protein -
DKC2_RS03425 727551..728498 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T285931 WP_003403218.1 NZ_LR027516:723187-723588 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT285931 WP_003403213.1 NZ_LR027516:722963-723190 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References