Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 715425..716068 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag DKC2_RS03335 Protein ID WP_003403187.1
Coordinates 715667..716068 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag DKC2_RS03330 Protein ID WP_003403184.1
Coordinates 715425..715670 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS03295 710705..711235 - 531 WP_003917320.1 two component system sensor kinase HK2 -
DKC2_RS03300 711219..711914 - 696 WP_003918099.1 two-component system response regulator TcrA -
DKC2_RS03305 712037..712348 + 312 WP_003403164.1 hypothetical protein -
DKC2_RS03310 712420..713370 + 951 WP_003900184.1 DUF1259 domain-containing protein -
DKC2_RS03315 713611..714195 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
DKC2_RS03320 714197..714907 + 711 Protein_641 transposase -
DKC2_RS03325 714910..715380 + 471 WP_003898523.1 hypothetical protein -
DKC2_RS03330 715425..715670 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DKC2_RS03335 715667..716068 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
DKC2_RS03350 716456..716623 - 168 WP_077385191.1 DUF3800 domain-containing protein -
DKC2_RS03355 716656..716853 - 198 WP_003403191.1 hypothetical protein -
DKC2_RS03360 716933..718090 - 1158 WP_003898524.1 hypothetical protein -
DKC2_RS03365 718142..718363 - 222 WP_003898525.1 DUF4926 domain-containing protein -
DKC2_RS03370 718505..719110 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T285930 WP_003403187.1 NZ_LR027516:715667-716068 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT285930 WP_003403184.1 NZ_LR027516:715425-715670 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References