Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 456422..457433 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag DKC2_RS02035 Protein ID WP_003401859.1
Coordinates 456422..457015 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag DKC2_RS02040 Protein ID WP_003401860.1
Coordinates 457044..457433 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS02015 452071..453453 + 1383 WP_003898415.1 magnesium transporter -
DKC2_RS02020 453465..454499 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
DKC2_RS02025 454595..455278 + 684 WP_003401857.1 VTT domain-containing protein -
DKC2_RS02030 455267..456397 - 1131 WP_003401858.1 hypothetical protein -
DKC2_RS02035 456422..457015 - 594 WP_003401859.1 zeta toxin family protein Toxin
DKC2_RS02040 457044..457433 - 390 WP_003401860.1 hypothetical protein Antitoxin
DKC2_RS02045 457514..458725 - 1212 WP_003906353.1 VWA domain-containing protein -
DKC2_RS02050 458731..459333 - 603 WP_003898417.1 SRPBCC family protein -
DKC2_RS02055 459347..460243 - 897 WP_003898418.1 MoxR family ATPase -
DKC2_RS02060 460240..460833 - 594 WP_003401864.1 NTP transferase domain-containing protein -
DKC2_RS02065 460830..461585 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T285925 WP_003401859.1 NZ_LR027516:c457015-456422 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT285925 WP_003401860.1 NZ_LR027516:c457433-457044 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References