Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0299-vapB/-
Location 375691..376262 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag DKC2_RS01695 Protein ID WP_003401560.1
Coordinates 375691..375993 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag DKC2_RS01700 Protein ID WP_003401563.1
Coordinates 376041..376262 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS01675 371160..371963 - 804 WP_003401540.1 hypothetical protein -
DKC2_RS01680 371973..373370 - 1398 WP_003401544.1 sulfatase -
DKC2_RS01685 373549..375324 + 1776 WP_010886074.1 PE family protein -
DKC2_RS01690 375467..375694 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
DKC2_RS01695 375691..375993 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
DKC2_RS01700 376041..376262 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
DKC2_RS01705 376259..376684 + 426 WP_003401566.1 PIN domain nuclease -
DKC2_RS01710 376820..377452 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
DKC2_RS01715 377449..378357 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T285923 WP_003401560.1 NZ_LR027516:375691-375993 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT285923 WP_003401563.1 NZ_LR027516:376041-376262 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References