Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3654861..3655544 Replicon chromosome
Accession NZ_LR026975
Organism Mycolicibacterium hassiacum DSM 44199 isolate Mhassiacum

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MHAS_RS17245 Protein ID WP_005629969.1
Coordinates 3654861..3655298 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID K5BAK9
Locus tag MHAS_RS17250 Protein ID WP_005629971.1
Coordinates 3655362..3655544 (-) Length 61 a.a.

Genomic Context

MHAS_RS17220MHAS_RS17225MHAS_RS17230MHAS_RS17235MHAS_RS17240MHAS_RS17245MHAS_RS17250MHAS_RS17255MHAS_RS17260
Location: 3650225..3651475 (1251 bp)
Type: Others
Protein ID: WP_005629953.1
Location: 3651472..3652515 (1044 bp)
Type: Others
Protein ID: WP_005629956.1
Location: 3652512..3652925 (414 bp)
Type: Others
Protein ID: WP_018353909.1
Location: 3652963..3654192 (1230 bp)
Type: Others
Protein ID: WP_005629963.1
Location: 3654204..3654857 (654 bp)
Type: Others
Protein ID: WP_005629965.1
Location: 3654861..3655298 (438 bp)
Type: Toxin
Protein ID: WP_005629969.1
Location: 3655362..3655544 (183 bp)
Type: Antitoxin
Protein ID: WP_005629971.1
Location: 3655550..3657958 (2409 bp)
Type: Others
Protein ID: WP_005629973.1
Location: 3657955..3659508 (1554 bp)
Type: Others
Protein ID: WP_005629974.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MHAS_RS172203650225..3651475+1251WP_005629953.1cytochrome P450-
MHAS_RS172253651472..3652515+1044WP_005629956.1dihydrodipicolinate reductase-
MHAS_RS172303652512..3652925+414WP_018353909.1hypothetical protein-
MHAS_RS172353652963..3654192+1230WP_005629963.1cytochrome P450-
MHAS_RS172403654204..3654857+654WP_005629965.1isomerase-
MHAS_RS172453654861..3655298-438WP_005629969.1SRPBCC family proteinToxin
MHAS_RS172503655362..3655544-183WP_005629971.1antitoxinAntitoxin
MHAS_RS172553655550..3657958-2409WP_005629973.1cation-translocating P-type ATPase-
MHAS_RS172603657955..3659508-1554WP_005629974.1serine hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15981.70 Da        Isoelectric Point: 10.1340

>T285920 WP_005629969.1 NZ_LR026975:c3655298-3654861 [Mycolicibacterium hassiacum DSM 44199]
MAKLSVSVDVPLPPEKAWECASDLSRYHEWLSIHRVWRSKLPETIEKGTVVESIVEVKGMLNRIRWKIVHYKPPEAMTLN
GDGVGGVKVKLIGKIRPSGEGSTVQFDIHLGGPALFGPIGMLVAAALRSDIQQSLNQFKRVFAPA

Download         Length: 438 bp

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6658.54 Da        Isoelectric Point: 5.0628

>AT285920 WP_005629971.1 NZ_LR026975:c3655544-3655362 [Mycolicibacterium hassiacum DSM 44199]
MSLLDKAKNLLAKNTDKVDAAIEKVGDIVDEKTQGKYAEHVDKVQEAAKDFVEKNLQDKA

Download         Length: 183 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBK5BAK9

References