Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3654861..3655544 Replicon chromosome
Accession NZ_LR026975
Organism Mycolicibacterium hassiacum DSM 44199 isolate Mhassiacum

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MHAS_RS17245 Protein ID WP_005629969.1
Coordinates 3654861..3655298 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID K5BAK9
Locus tag MHAS_RS17250 Protein ID WP_005629971.1
Coordinates 3655362..3655544 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHAS_RS17220 3650225..3651475 + 1251 WP_005629953.1 cytochrome P450 -
MHAS_RS17225 3651472..3652515 + 1044 WP_005629956.1 dihydrodipicolinate reductase -
MHAS_RS17230 3652512..3652925 + 414 WP_018353909.1 hypothetical protein -
MHAS_RS17235 3652963..3654192 + 1230 WP_005629963.1 cytochrome P450 -
MHAS_RS17240 3654204..3654857 + 654 WP_005629965.1 isomerase -
MHAS_RS17245 3654861..3655298 - 438 WP_005629969.1 SRPBCC family protein Toxin
MHAS_RS17250 3655362..3655544 - 183 WP_005629971.1 antitoxin Antitoxin
MHAS_RS17255 3655550..3657958 - 2409 WP_005629973.1 cation-translocating P-type ATPase -
MHAS_RS17260 3657955..3659508 - 1554 WP_005629974.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15981.70 Da        Isoelectric Point: 10.1340

>T285920 WP_005629969.1 NZ_LR026975:c3655298-3654861 [Mycolicibacterium hassiacum DSM 44199]
MAKLSVSVDVPLPPEKAWECASDLSRYHEWLSIHRVWRSKLPETIEKGTVVESIVEVKGMLNRIRWKIVHYKPPEAMTLN
GDGVGGVKVKLIGKIRPSGEGSTVQFDIHLGGPALFGPIGMLVAAALRSDIQQSLNQFKRVFAPA

Download         Length: 438 bp

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6658.54 Da        Isoelectric Point: 5.0628

>AT285920 WP_005629971.1 NZ_LR026975:c3655544-3655362 [Mycolicibacterium hassiacum DSM 44199]
MSLLDKAKNLLAKNTDKVDAAIEKVGDIVDEKTQGKYAEHVDKVQEAAKDFVEKNLQDKA

Download         Length: 183 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB K5BAK9

References